Table of Contents
1.1 List of Tables 9
1.2 List of Figures 11
2 Gastrointestinal Therapeutics in Major Developed Markets – Introduction 12
2.1 Irritable Bowel Syndrome 12
2.1.1 Classification 12
2.1.2 Symptoms 12
2.1.3 Etiology 12
2.1.4 Pathophysiology 13
2.1.5 Diagnosis 13
2.1.6 Epidemiology 14
2.1.7 Prognosis 15
2.1.8 Treatment Options 15
2.2 Ulcerative Colitis 16
2.2.1 Classification 16
2.2.2 Symptoms 17
2.2.3 Etiology 17
2.2.4 Pathophysiology 18
2.2.5 Diagnosis 18
2.2.6 Epidemiology 19
2.2.7 Prognosis 19
2.2.8 Treatment Options 20
2.3 Crohn’s Disease 21
2.3.1 Classification 21
2.3.2 Symptoms 22
2.3.3 Etiology 22
2.3.4 Pathophysiology 23
2.3.5 Diagnosis 23
2.3.6 Epidemiology 24
2.3.7 Prognosis 24
2.3.8 Treatment Options 25
3 Gastrointestinal Therapeutics in Major Developed Markets – Marketed Products (Global) 26
3.1 Irritable Bowel Syndrome 26
3.2 Ulcerative Colitis 26
3.3 Crohn’s Disease 26
3.4 Key Marketed Products 27
3.4.1 Amitiza 27
3.4.2 Humira 28
3.4.3 Remicade 29
3.4.4 Simponi 30
3.4.5 Cimzia 31
3.4.6 Tysabri 32
4 Gastrointestinal Therapeutics in Major Developed Markets – Pipeline Analysis 34
4.1 Irritable Bowel Syndrome 34
4.1.1 Overall Pipeline 34
4.1.2 Pipeline Analysis by Molecule Type 36
4.1.3 Pipeline Analysis by Mechanism of Action 37
4.2 Ulcerative Colitis Pipeline 39
4.2.1 Overall Pipeline 39
4.2.2 Pipeline Analysis by Molecule Type 41
4.2.3 Pipeline Analysis by Mechanism of Action 42
4.3 Crohn’s Disease Pipeline 44
4.3.1 Overall Pipeline 44
4.3.2 Pipeline Analysis by Molecule Type 46
4.3.3 Pipeline Analysis by Mechanism of Action 47
4.4 Promising Drug Candidates in the Pipeline 49
4.4.1 GSK-1605786 49
4.4.2 MLN0002 49
4.4.3 EMD-61753 49
5 Gastrointestinal Therapeutics in Major Developed Markets – Market Forecast to 2019 50
5.1 Major Developed Markets 50
5.1.1 Treatment Usage Patterns 50
5.1.2 Annual Cost of Therapy 50
5.1.3 Market Size 50
5.2 US 52
5.2.1 Treatment Usage Patterns 52
5.2.2 Annual Cost of Therapy 52
5.2.3 Market Size 52
5.3 Europe 54
5.3.1 Treatment Usage Patterns 54
5.3.2 Annual Cost of Therapy 54
5.3.3 Market Size 54
5.4 Canada 56
5.4.1 Treatment Usage Patterns 56
5.4.2 Annual Cost of Therapy 56
5.4.3 Market Size 56
5.5 Japan 58
5.5.1 Treatment Usage Patterns 58
5.5.2 Annual Cost of Therapy 58
5.5.3 Market Size 58
5.6 Drivers and Barriers 60
5.6.1 Drivers 60
5.6.2 Barriers 60
6 Gastrointestinal Therapeutics in Major Developed Markets – Deals and Strategic Consolidations (Global) 62
6.1 Deals Analysis 62
6.2 Major Co-Development Deals 64
6.2.1 AstraZeneca Enters into Co-Development Agreement with Ironwood Pharma for Linaclotide 65
6.2.2 Amgen Enters into Co-development Agreement with AstraZeneca for Five Monoclonal Antibodies 65
6.2.3 Galapagos and AbbVie Extend GLPG0634 Development Agreement to Include Crohn's Disease 65
6.3 Major Licensing Deals 66
6.3.1 AstraZeneca Enters into Licensing Agreement with Ardelyx for NHE3 Inhibitor Program 67
6.3.2 Sanofi-Aventis Enters into Licensing Agreement with Kyowa Hakko Kirin 67
6.3.3 GlaxoSmithKline Enters into Licensing Agreement with ChemoCentryx 67
7 Gastrointestinal Therapeutics in Major Developed Markets – Appendix 68
7.1 All Pipeline Drugs by Phase 68
7.1.1 Discovery 68
7.1.2 Preclinical 68
7.1.3 IND/CTA-filed 69
7.1.4 Phase I 70
7.1.5 Phase II 71
7.1.6 Phase III 73
7.1.7 Pre-Registration 73
7.1.8 Undisclosed 74
7.2 Market Forecasts to 2019 74
7.2.1 Major Developed Markets 74
7.2.2 US 75
7.2.3 Canada 76
7.2.4 UK 77
7.2.5 France 78
7.2.6 Germany 79
7.2.7 Italy 80
7.2.8 Spain 81
7.2.9 Japan 82
7.3 Market Definitions 83
7.4 Abbreviations 83
7.5 Sources 85
7.6 Research Methodology 87
7.6.1 Coverage 87
7.6.2 Secondary Research 87
7.6.3 Primary Research 88
7.6.4 Therapeutic Landscape 88
7.6.5 Geographical Landscape 91
7.6.6 Pipeline Analysis 91
7.7 Expert Panel Validation 91
7.8 Contact Us 91
7.9 Disclaimer 91