Toxicology Cluster Chemotherapy Related Toxicity Drug Development Pipeline Review, 2017

This report provides an overview of the toxicology pipeline landscape. The report provides comprehensive information on the therapeutics under development and key players involved in therapeutic development for Chemotherapy Induced Nausea and Vomiting, Chemotherapy Induced Neutropenia, Chemotherapy Induced Anemia, Chemotherapy Induced Peripheral Neuropathy and features dormant and discontinued projects.

These key indications are all common side effects of cancer chemotherapy treatment, and result in a substantial reduction in the patient’s quality of life. Chemotherapy induced nausea and vomiting or CINV is nausea and vomiting that results specifically from treatment with chemotherapy drugs. Chemotherapy-induced neutropenia is another very common side effect of cancer treatment. Symptoms include severe fatigue, weakness, anxiety, lack of energy, shortness of breath, headaches, pale appearance, rapid heart rate or palpitations, chest pain dizziness and abdominal pain. Chemotherapy-induced anemia symptoms include severe fatigue, weakness, anxiety, lack of energy, shortness of breath, headaches, pale appearance, rapid heart rate or palpitations, chest pain dizziness, cognitive impairment, loss of sexual desire, inability to perform daily functions and/or depression associated with anemia. Finally, chemotherapy-induced peripheral neuropathy (CIPN) is a further potential side effect of cancer treatment. Symptoms include pain, burning, tingling, constipation, muscle weakness, blood pressure changes and balance problems.

The size of these pipelines ranges from 16 in chemotherapy-induced anemia to 41 in chemotherapy-induced neutropenia and CIPN. In CINV and CIPN, there is a relatively diverse range of targets which are being studied, although most of these targets are neurotransmitter receptors. On the other hand, the pipelines for chemotherapy-induced neutropenia and anemia are far more limited in the range of molecular targets being studied.

Scope

– Which companies are the most active within the pipeline for toxicology therapeutics?

– Which pharmaceutical approaches are the most prominent at each stage of the pipeline and within each indication?

– To what extent do universities and institutions play a role within this pipeline, compared to pharmaceutical companies?

– What are the most important R&D milestones and data publications to have happened in the field of toxicology therapeutics?

Reasons to buy

- Understand the overall pipeline, with an at-a-glance overview of all products in therapeutic development for each indication

- Assess the products in development in granular detail, with an up-to-date overview of each individual pipeline program in each indication, and a comprehensive picture of recent updates and milestones for each

- Analyze the companies, institutions and universities currently operating in the pipeline, and the products being fielded by each of these

- Understand the composition of the pipeline in terms of molecule type, molecular target, mechanism of action and route of administration

Table of Contents

Table of Contents

GBI Research Report Guidance 2

Executive Summary 3

Table of Contents 4

List of Tables 6

List of Figures 9

Introduction 10

Toxicology Cluster Chemotherapy Related Toxicity Report Coverage 10

Chemotherapy Induced Nausea and Vomiting – Overview 10

Chemotherapy Induced Neutropenia – Overview 10

Chemotherapy Induced Anemia – Overview 10

Chemotherapy Induced Peripheral Neuropathy – Overview 10

Therapeutics Development 11

Chemotherapy Induced Nausea and Vomiting 11

Chemotherapy Induced Neutropenia 15

Chemotherapy Induced Anemia 20

Chemotherapy Induced Peripheral Neuropathy 23

Therapeutics Assessment 30

Chemotherapy Induced Nausea and Vomiting 30

Chemotherapy Induced Neutropenia 37

Chemotherapy Induced Anemia 45

Chemotherapy Induced Peripheral Neuropathy 53

Companies Involved in Therapeutics Development 61

Chemotherapy Induced Nausea and Vomiting 61

Chemotherapy Induced Neutropenia 70

Chemotherapy Induced Anemia 82

Chemotherapy Induced Peripheral Neuropathy 89

Dormant Projects 103

Chemotherapy Induced Nausea and Vomiting 103

Chemotherapy Induced Neutropenia 104

Chemotherapy Induced Anemia 105

Chemotherapy Induced Peripheral Neuropathy 106

Discontinued Products 107

Chemotherapy Induced Nausea and Vomiting 107

Chemotherapy Induced Neutropenia 107

Chemotherapy Induced Anemia 108

Chemotherapy Induced Peripheral Neuropathy 108

Product Development Milestones 109

Chemotherapy Induced Nausea and Vomiting 109

Chemotherapy Induced Neutropenia 116

Chemotherapy Induced Anemia 125

Chemotherapy Induced Peripheral Neuropathy 131

Appendix 138

Methodology 138

Coverage 138

Secondary Research 138

Primary Research 138

Expert Panel Validation 138

Contact Us 139

Disclaimer 139

List of Tables

List of Tables

Number of Products under Development for Chemotherapy Induced Nausea and Vomiting 11

Number of Products under Development by Companies, Chemotherapy Induced Nausea and Vomiting 13

Products under Development by Companies, Chemotherapy Induced Nausea and Vomiting 14

Number of Products under Development for Chemotherapy Induced Neutropenia 16

Number of Products under Development by Companies, Chemotherapy Induced Neutropenia 17

Number of Products under Development by Universities/Institutes, Chemotherapy Induced Neutropenia 17

Products under Development by Companies, Chemotherapy Induced Neutropenia 18

Products under Development by Universities/Institutes, Chemotherapy Induced Neutropenia 20

Number of Products under Development for Chemotherapy Induced Anemia 20

Number of Products under Development by Companies, Chemotherapy Induced Anemia 21

Products under Development by Companies, Chemotherapy Induced Anemia 22

Number of Products under Development for Chemotherapy Induced Peripheral Neuropathy 23

Number of Products under Development by Companies, Chemotherapy Induced Peripheral Neuropathy 25

Number of Products under Development by Universities/Institutes, Chemotherapy Induced Peripheral Neuropathy 26

Products under Development by Companies, Chemotherapy Induced Peripheral Neuropathy 27

Products under Development by Universities/Institutes, Chemotherapy Induced Peripheral Neuropathy 29

Number of Products by Stage and Target, Chemotherapy Induced Nausea and Vomiting 31

Number of Products by Stage and Mechanism of Action, Chemotherapy Induced Nausea and Vomiting 33

Number of Products by Stage and Route of Administration, Chemotherapy Induced Nausea and Vomiting 35

Number of Products by Stage and Molecule Type, Chemotherapy Induced Nausea and Vomiting 36

Number of Products by Stage and Target, Chemotherapy Induced Neutropenia 38

Number of Products by Stage and Mechanism of Action, Chemotherapy Induced Neutropenia 40

Number of Products by Stage and Route of Administration, Chemotherapy Induced Neutropenia 42

Number of Products by Stage and Molecule Type, Chemotherapy Induced Neutropenia 44

Number of Products by Stage and Target, Chemotherapy Induced Anemia 46

Number of Products by Stage and Mechanism of Action, Chemotherapy Induced Anemia 48

Number of Products by Stage and Route of Administration, Chemotherapy Induced Anemia 50

Number of Products by Stage and Molecule Type, Chemotherapy Induced Anemia 52

Number of Products by Stage and Target, Chemotherapy Induced Peripheral Neuropathy 54

Number of Products by Stage and Mechanism of Action, Chemotherapy Induced Peripheral Neuropathy 56

Number of Products by Stage and Route of Administration, Chemotherapy Induced Peripheral Neuropathy 58

Number of Products by Stage and Molecule Type, Chemotherapy Induced Peripheral Neuropathy 60

Chemotherapy Induced Nausea and Vomiting – Pipeline by Acacia Pharma Ltd 61

Chemotherapy Induced Nausea and Vomiting – Pipeline by Aphios Corp 61

Chemotherapy Induced Nausea and Vomiting – Pipeline by Astellas Pharma Inc 62

Chemotherapy Induced Nausea and Vomiting – Pipeline by Camurus AB 62

Chemotherapy Induced Nausea and Vomiting – Pipeline by Daewoong Pharmaceutical Co Ltd 63

Chemotherapy Induced Nausea and Vomiting – Pipeline by Heron Therapeutics Inc 63

Chemotherapy Induced Nausea and Vomiting – Pipeline by INSYS Therapeutics Inc 64

Chemotherapy Induced Nausea and Vomiting – Pipeline by Kyowa Hakko Kirin Co Ltd 64

Chemotherapy Induced Nausea and Vomiting – Pipeline by MannKind Corp 65

Chemotherapy Induced Nausea and Vomiting – Pipeline by Medlab Clinical Ltd 65

Chemotherapy Induced Nausea and Vomiting – Pipeline by Nemus Bioscience Inc 66

Chemotherapy Induced Nausea and Vomiting – Pipeline by RedHill Biopharma Ltd 66

Chemotherapy Induced Nausea and Vomiting – Pipeline by Serina Therapeutics Inc 67

Chemotherapy Induced Nausea and Vomiting – Pipeline by SoluBest Ltd 67

Chemotherapy Induced Nausea and Vomiting – Pipeline by Suda Ltd 68

Chemotherapy Induced Nausea and Vomiting – Pipeline by Tesaro Inc 68

Chemotherapy Induced Nausea and Vomiting – Pipeline by Therapix Biosciences Ltd 69

Chemotherapy Induced Neutropenia – Pipeline by Apotex Inc 70

Chemotherapy Induced Neutropenia – Pipeline by Biocon Ltd 70

Chemotherapy Induced Neutropenia – Pipeline by Biogenomics Ltd 71

Chemotherapy Induced Neutropenia – Pipeline by Bolder Biotechnology Inc 71

Chemotherapy Induced Neutropenia – Pipeline by Cellerant Therapeutics Inc 72

Chemotherapy Induced Neutropenia – Pipeline by Chong Kun Dang Pharmaceutical Corp 72

Chemotherapy Induced Neutropenia – Pipeline by Cinfa Biotech SL 73

Chemotherapy Induced Neutropenia – Pipeline by Dr. Reddy’s Laboratories Ltd 73

Chemotherapy Induced Neutropenia – Pipeline by Gene Techno Science Co Ltd 74

Chemotherapy Induced Neutropenia – Pipeline by Generon (Shanghai) Corp Ltd 74

Chemotherapy Induced Neutropenia – Pipeline by Genexine Inc 75

Chemotherapy Induced Neutropenia – Pipeline by GlycoMimetics Inc 75

Chemotherapy Induced Neutropenia – Pipeline by Hanmi Pharmaceuticals Co Ltd 76

Chemotherapy Induced Neutropenia – Pipeline by Mycenax Biotech Inc 76

Chemotherapy Induced Neutropenia – Pipeline by Myelo Therapeutics GmbH 77

Chemotherapy Induced Neutropenia – Pipeline by Nohla Therapeutics Inc 77

Chemotherapy Induced Neutropenia – Pipeline by Octapharma AG 78

Chemotherapy Induced Neutropenia – Pipeline by Pfenex Inc 78

Chemotherapy Induced Neutropenia – Pipeline by Pfizer Inc 79

Chemotherapy Induced Neutropenia – Pipeline by Reliance Life Sciences Pvt Ltd 79

Chemotherapy Induced Neutropenia – Pipeline by Richter Gedeon Nyrt 80

Chemotherapy Induced Neutropenia – Pipeline by Sandoz International GmbH 80

Chemotherapy Induced Neutropenia – Pipeline by USV Pvt Ltd 81

Chemotherapy Induced Anemia – Pipeline by 3SBio Inc 82

Chemotherapy Induced Anemia – Pipeline by Chong Kun Dang Pharmaceutical Corp 82

Chemotherapy Induced Anemia – Pipeline by Dr. Reddy’s Laboratories Ltd 83

Chemotherapy Induced Anemia – Pipeline by Galenica Ltd 83

Chemotherapy Induced Anemia – Pipeline by Novartis AG 84

Chemotherapy Induced Anemia – Pipeline by Panacea Biotec Ltd 84

Chemotherapy Induced Anemia – Pipeline by Pfizer Inc 85

Chemotherapy Induced Anemia – Pipeline by PharmaEssentia Corp 85

Chemotherapy Induced Anemia – Pipeline by PhytoHealth Corp 86

Chemotherapy Induced Anemia – Pipeline by Pieris Pharmaceuticals Inc 86

Chemotherapy Induced Anemia – Pipeline by SBI Pharmaceuticals Co Ltd 87

Chemotherapy Induced Anemia – Pipeline by Therapure Biopharma Inc 87

Chemotherapy Induced Anemia – Pipeline by Tolero Pharmaceuticals Inc 88

Chemotherapy Induced Peripheral Neuropathy – Pipeline by Achelios Therapeutics Inc 89

Chemotherapy Induced Peripheral Neuropathy – Pipeline by Advinus Therapeutics Ltd 89

Chemotherapy Induced Peripheral Neuropathy – Pipeline by Apollo Endosurgery Inc 90

Chemotherapy Induced Peripheral Neuropathy – Pipeline by Aptinyx Inc 90

Chemotherapy Induced Peripheral Neuropathy – Pipeline by Asahi Kasei Pharma Corp 91

Chemotherapy Induced Peripheral Neuropathy – Pipeline by Can-Fite BioPharma Ltd 91

Chemotherapy Induced Peripheral Neuropathy – Pipeline by Celgene Corp 92

Chemotherapy Induced Peripheral Neuropathy – Pipeline by DermaXon LLC 92

Chemotherapy Induced Peripheral Neuropathy – Pipeline by Eisai Co Ltd 93

Chemotherapy Induced Peripheral Neuropathy – Pipeline by Immune Pharmaceuticals Inc 93

Chemotherapy Induced Peripheral Neuropathy – Pipeline by INSYS Therapeutics Inc 94

Chemotherapy Induced Peripheral Neuropathy – Pipeline by Kineta Inc 94

Chemotherapy Induced Peripheral Neuropathy – Pipeline by KPI Therapeutics Inc 95

Chemotherapy Induced Peripheral Neuropathy – Pipeline by Krenitsky Pharmaceuticals Inc 95

Chemotherapy Induced Peripheral Neuropathy – Pipeline by MAKScientific LLC 96

Chemotherapy Induced Peripheral Neuropathy – Pipeline by Metys Pharmaceuticals AG 96

Chemotherapy Induced Peripheral Neuropathy – Pipeline by Midatech Pharma US Inc 97

Chemotherapy Induced Peripheral Neuropathy – Pipeline by Mundipharma International Ltd 97

Chemotherapy Induced Peripheral Neuropathy – Pipeline by Nemus Bioscience Inc 98

Chemotherapy Induced Peripheral Neuropathy – Pipeline by Neurocentrx Pharma Ltd 98

Chemotherapy Induced Peripheral Neuropathy – Pipeline by Panacea Pharmaceuticals Inc 99

Chemotherapy Induced Peripheral Neuropathy – Pipeline by PeriphaGen Inc 99

Chemotherapy Induced Peripheral Neuropathy – Pipeline by PharmatrophiX Inc 100

Chemotherapy Induced Peripheral Neuropathy – Pipeline by PledPharma AB 100

Chemotherapy Induced Peripheral Neuropathy – Pipeline by Sova Pharmaceuticals Inc 101

Chemotherapy Induced Peripheral Neuropathy – Pipeline by Virobay Inc 101

Chemotherapy Induced Peripheral Neuropathy – Pipeline by WEX Pharmaceuticals Inc 102

Chemotherapy Induced Nausea and Vomiting – Dormant Projects 103

Chemotherapy Induced Neutropenia – Dormant Projects 104

Chemotherapy Induced Anemia – Dormant Projects 105

Chemotherapy Induced Peripheral Neuropathy – Dormant Projects 106

Chemotherapy Induced Nausea and Vomiting – Discontinued Products 107

Chemotherapy Induced Neutropenia – Discontinued Products 107

Chemotherapy Induced Anemia – Discontinued Products 108

Chemotherapy Induced Peripheral Neuropathy – Discontinued Products 108

List of Figures

List of Figures

Number of Products under Development for Chemotherapy Induced Nausea and Vomiting 11

Number of Products under Development by Companies, Chemotherapy Induced Nausea and Vomiting 12

Number of Products under Development for Chemotherapy Induced Neutropenia 15

Number of Products under Development by Companies, Chemotherapy Induced Neutropenia 16

Number of Products under Development for Chemotherapy Induced Anemia 20

Number of Products under Development by Companies, Chemotherapy Induced Anemia 21

Number of Products under Development for Chemotherapy Induced Peripheral Neuropathy 23

Number of Products under Development by Companies, Chemotherapy Induced Peripheral Neuropathy 24

Number of Products under Development by Universities/Institutes, Chemotherapy Induced Peripheral Neuropathy 26

Number of Products by Targets, Chemotherapy Induced Nausea and Vomiting 30

Number of Products by Stage and Targets, Chemotherapy Induced Nausea and Vomiting 30

Number of Products by Mechanism of Actions, Chemotherapy Induced Nausea and Vomiting 32

Number of Products by Stage and Mechanism of Actions, Chemotherapy Induced Nausea and Vomiting 32

Number of Products by Top 10 Routes of Administration, Chemotherapy Induced Nausea and Vomiting 34

Number of Products by Stage and Top 10 Routes of Administration, Chemotherapy Induced Nausea and Vomiting 34

Number of Products by Stage and Molecule Types, Chemotherapy Induced Nausea and Vomiting 36

Number of Products by Targets, Chemotherapy Induced Neutropenia 37

Number of Products by Stage and Targets, Chemotherapy Induced Neutropenia 37

Number of Products by Mechanism of Actions, Chemotherapy Induced Neutropenia 39

Number of Products by Stage and Mechanism of Actions, Chemotherapy Induced Neutropenia 39

Number of Products by Routes of Administration, Chemotherapy Induced Neutropenia 41

Number of Products by Stage and Routes of Administration, Chemotherapy Induced Neutropenia 41

Number of Products by Molecule Types, Chemotherapy Induced Neutropenia 43

Number of Products by Stage and Molecule Types, Chemotherapy Induced Neutropenia 43

Number of Products by Targets, Chemotherapy Induced Anemia 45

Number of Products by Stage and Targets, Chemotherapy Induced Anemia 45

Number of Products by Mechanism of Actions, Chemotherapy Induced Anemia 47

Number of Products by Stage and Mechanism of Actions, Chemotherapy Induced Anemia 47

Number of Products by Routes of Administration, Chemotherapy Induced Anemia 49

Number of Products by Stage and Routes of Administration, Chemotherapy Induced Anemia 49

Number of Products by Molecule Types, Chemotherapy Induced Anemia 51

Number of Products by Stage and Molecule Types, Chemotherapy Induced Anemia 51

Number of Products by Top 10 Targets, Chemotherapy Induced Peripheral Neuropathy 53

Number of Products by Stage and Top 10 Targets, Chemotherapy Induced Peripheral Neuropathy 53

Number of Products by Top 10 Mechanism of Actions, Chemotherapy Induced Peripheral Neuropathy 55

Number of Products by Stage and Top 10 Mechanism of Actions, Chemotherapy Induced Peripheral Neuropathy 55

Number of Products by Routes of Administration, Chemotherapy Induced Peripheral Neuropathy 57

Number of Products by Stage and Routes of Administration, Chemotherapy Induced Peripheral Neuropathy 57

Number of Products by Molecule Types, Chemotherapy Induced Peripheral Neuropathy 59

Number of Products by Stage and Molecule Types, Chemotherapy Induced Peripheral Neuropathy 59

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