Swine and Avian Influenza Drug Development Pipeline Review, 2017

This report provides an overview of the Swine and Avian Influenza pipeline landscape. The report provides comprehensive information on the therapeutics under development and key players involved in therapeutic development for influenza A virus, subtypes H5N1 and H1N1, and features dormant and discontinued projects.

H5N1 is a type of influenza virus that causes a highly infectious, severe respiratory disease in birds called avian influenza. This virus can spread to humans. There are a total of 63 products in development for this indication, by 47 companies and six academic institutions.

H1N1 Infection also called as swine flu is a new kind of flu in humans. It’s caused by the contagious H1N1 influenza virus. There are a total of 99 products in development for this indication, by 67 companies and 14 academic institutions.

In both types of influenza, the most common molecular target being studied is hemagglutinin, by a considerable margin. However, a number of both human and viral proteins are also under active development.

Scope

– Which companies are the most active within each pipeline?

– Which pharmaceutical approaches are the most prominent at each stage of the pipeline and within each indication?

– To what extent do universities and institutions play a role within this pipeline, compared to pharmaceutical companies?

– What are the most important R&D milestones and data publications to have happened in this disease area?

Reasons to buy

- Understand the overall pipeline, with an at-a-glance overview of all products in therapeutic development for each indication

- Assess the products in development in granular detail, with an up-to-date overview of each individual pipeline program in each indication, and a comprehensive picture of recent updates and milestones for each

- Analyze the companies, institutions and universities currently operating in the pipeline, and the products being fielded by each of these

- Understand the composition of the pipeline in terms of molecule type, molecular target, mechanism of action and route of administration

Table of Contents

1 Table of Contents

1 Table of Contents 4

1.1 List of Tables 5

1.2 List of Figures 7

2 Introduction 8

2.1 Swine and Avian Influenza Report Coverage 8

2.2 Influenza A Virus, H5N1 Subtype Infections – Overview 8

2.3 Influenza A Virus, H1N1 Subtype Infections – Overview 8

3 Therapeutics Development 9

3.1 Influenza A Virus, H5N1 Subtype Infections 9

3.2 Influenza A Virus, H1N1 Subtype Infections 18

4 Therapeutics Assessment 30

4.1 Influenza A Virus, H5N1 Subtype Infections 30

4.2 Influenza A Virus, H1N1 Subtype Infections 36

5 Companies Involved in Therapeutics Development 43

5.1 Influenza A Virus, H5N1 Subtype Infections 43

5.2 Influenza A Virus, H1N1 Subtype Infections 58

6 Dormant Projects 81

6.1 Influenza A Virus, H5N1 Subtype Infections 81

6.2 Influenza A Virus, H1N1 Subtype Infections 86

7 Discontinued Products 90

7.1 Influenza A Virus, H5N1 Subtype Infections 90

7.2 Influenza A Virus, H1N1 Subtype Infections 90

8 Product Development Milestones 91

8.1 Influenza A Virus, H5N1 Subtype Infections 91

8.2 Influenza A Virus, H1N1 Subtype Infections 103

9 Appendix 118

9.1 Methodology 118

9.2 Coverage 118

9.3 Secondary Research 118

9.4 Primary Research 118

9.5 Expert Panel Validation 118

9.6 Contact Us 119

9.7 Disclaimer 119

List of Tables

1.1 List of Tables

Table 1: Number of Products under Development for Influenza A Virus, H5N1 Subtype Infections 9

Table 2: Number of Products under Development by Companies Influenza A Virus, H5N1 Subtype Infections 11

Table 3: Number of Products under Development by Universities/Institutes Influenza A Virus, H5N1 Subtype Infections 13

Table 4: Products under Development by Companies Influenza A Virus, H5N1 Subtype Infections 14

Table 5: Products under Development by Universities/Institutes Influenza A Virus, H5N1 Subtype Infections 17

Table 6: Number of Products under Development for Influenza A Virus, H1N1 Subtype Infections 18

Table 7: Number of Products under Development by Companies Influenza A Virus, H1N1 Subtype Infections 20

Table 8: Number of Products under Development by Universities/Institutes Influenza A Virus, H1N1 Subtype Infections 22

Table 9: Products under Development by Companies Influenza A Virus, H1N1 Subtype Infections 23

Table 10: Products under Development by Universities/Institutes Influenza A Virus, H1N1 Subtype Infections 28

Table 11: Number of Products by Stage and Target Influenza A Virus, H5N1 Subtype Infections 31

Table 12: Number of Products by Stage and Mechanism of Action Influenza A Virus, H5N1 Subtype Infections 32

Table 13: Number of Products by Stage and Route of Administration Influenza A Virus, H5N1 Subtype Infections 34

Table 14: Number of Products by Stage and Molecule Type Influenza A Virus, H5N1 Subtype Infections 35

Table 15: Number of Products by Stage and Target Influenza A Virus, H1N1 Subtype Infections 37

Table 16: Number of Products by Stage and Mechanism of Action Influenza A Virus, H1N1 Subtype Infections 39

Table 17: Number of Products by Stage and Route of Administration Influenza A Virus, H1N1 Subtype Infections 41

Table 18: Number of Products by Stage and Molecule Type Influenza A Virus, H1N1 Subtype Infections 42

Table 19: Influenza A Virus, H5N1 Subtype Infections – Pipeline by Akshaya Bio Inc 43

Table 20: Influenza A Virus, H5N1 Subtype Infections – Pipeline by Altimmune Inc 43

Table 21: Influenza A Virus, H5N1 Subtype Infections – Pipeline by Antigen Express Inc 44

Table 22: Influenza A Virus, H5N1 Subtype Infections – Pipeline by Aphios Corp 44

Table 23: Influenza A Virus, H5N1 Subtype Infections – Pipeline by BiondVax Pharmaceuticals Ltd 45

Table 24: Influenza A Virus, H5N1 Subtype Infections – Pipeline by CEL-SCI Corp 45

Table 25: Influenza A Virus, H5N1 Subtype Infections – Pipeline by Cocrystal Pharma Inc 46

Table 26: Influenza A Virus, H5N1 Subtype Infections – Pipeline by Curevac AG 46

Table 27: Influenza A Virus, H5N1 Subtype Infections – Pipeline by Gemmus Pharma Inc 47

Table 28: Influenza A Virus, H5N1 Subtype Infections – Pipeline by GlaxoSmithKline Plc 47

Table 29: Influenza A Virus, H5N1 Subtype Infections – Pipeline by Hemispherx Biopharma Inc 48

Table 30: Influenza A Virus, H5N1 Subtype Infections – Pipeline by iBio Inc 48

Table 31: Influenza A Virus, H5N1 Subtype Infections – Pipeline by Inovio Pharmaceuticals Inc 49

Table 32: Influenza A Virus, H5N1 Subtype Infections – Pipeline by Johnson & Johnson 49

Table 33: Influenza A Virus, H5N1 Subtype Infections – Pipeline by Kineta Inc 50

Table 34: Influenza A Virus, H5N1 Subtype Infections – Pipeline by Lakewood-Amedex Inc 50

Table 35: Influenza A Virus, H5N1 Subtype Infections – Pipeline by Medicago Inc 51

Table 36: Influenza A Virus, H5N1 Subtype Infections – Pipeline by Medigen Vaccine Biologics Corp 51

Table 37: Influenza A Virus, H5N1 Subtype Infections – Pipeline by Microbiotix Inc 52

Table 38: Influenza A Virus, H5N1 Subtype Infections – Pipeline by NanoBio Corp 52

Table 39: Influenza A Virus, H5N1 Subtype Infections – Pipeline by Nanotherapeutics Inc 53

Table 40: Influenza A Virus, H5N1 Subtype Infections – Pipeline by NanoViricides Inc 53

Table 41: Influenza A Virus, H5N1 Subtype Infections – Pipeline by OPKO Health Inc 54

Table 42: Influenza A Virus, H5N1 Subtype Infections – Pipeline by PaxVax Inc 54

Table 43: Influenza A Virus, H5N1 Subtype Infections – Pipeline by PeptiDream Inc 55

Table 44: Influenza A Virus, H5N1 Subtype Infections – Pipeline by Shionogi & Co Ltd 56

Table 45: Influenza A Virus, H5N1 Subtype Infections – Pipeline by Takeda Pharmaceutical Company Ltd 56

Table 46: Influenza A Virus, H5N1 Subtype Infections – Pipeline by TechnoVax Inc 56

Table 47: Influenza A Virus, H5N1 Subtype Infections – Pipeline by Vaxart Inc 57

Table 48: Influenza A Virus, H5N1 Subtype Infections – Pipeline by Vaxine Pty Ltd 57

Table 49: Influenza A Virus, H5N1 Subtype Infections – Pipeline by Visterra Inc 58

Table 50: Influenza A Virus, H1N1 Subtype Infections – Pipeline by AbbVie Inc 58

Table 51: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Adimmune Corp 59

Table 52: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Akshaya Bio Inc 59

Table 53: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Altimmune Inc 60

Table 54: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Antigen Express Inc 60

Table 55: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Beijing Minhai Biotechnology Co Ltd 61

Table 56: Influenza A Virus, H1N1 Subtype Infections – Pipeline by BioCryst Pharmaceuticals Inc 61

Table 57: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Cadila Healthcare Ltd 62

Table 58: Influenza A Virus, H1N1 Subtype Infections – Pipeline by CEL-SCI Corp 62

Table 59: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Cilian AG 63

Table 60: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Cocrystal Pharma Inc 63

Table 61: Influenza A Virus, H1N1 Subtype Infections – Pipeline by ContraFect Corp 64

Table 62: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Curevac AG 64

Table 63: Influenza A Virus, H1N1 Subtype Infections – Pipeline by EpiVax Inc 65

Table 64: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Etubics Corp 65

Table 65: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Gemmus Pharma Inc 66

Table 66: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Genentech Inc 66

Table 67: Influenza A Virus, H1N1 Subtype Infections – Pipeline by iBio Inc 67

Table 68: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Inovio Pharmaceuticals Inc 67

Table 69: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Jiangsu Kanion Pharmaceutical Co Ltd 68

Table 70: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Johnson & Johnson 69

Table 71: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Kineta Inc 69

Table 72: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Kyowa Hakko Kirin Co Ltd 70

Table 73: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Lakewood-Amedex Inc 70

Table 74: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Medicago Inc 71

Table 75: Influenza A Virus, H1N1 Subtype Infections – Pipeline by MedImmune LLC 71

Table 76: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Microbiotix Inc 72

Table 77: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Mucosis BV 72

Table 78: Influenza A Virus, H1N1 Subtype Infections – Pipeline by NanoViricides Inc 73

Table 79: Influenza A Virus, H1N1 Subtype Infections – Pipeline by NewLink Genetics Corp 73

Table 80: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Novavax Inc 74

Table 81: Influenza A Virus, H1N1 Subtype Infections – Pipeline by OPKO Health Inc 74

Table 82: Influenza A Virus, H1N1 Subtype Infections – Pipeline by PeptiDream Inc 75

Table 83: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Recce Ltd 75

Table 84: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Sanofi 75

Table 85: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Sanofi Pasteur SA 76

Table 86: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Sarepta Therapeutics Inc 77

Table 87: Influenza A Virus, H1N1 Subtype Infections – Pipeline by SK Chemicals Co Ltd 77

Table 88: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Takeda Pharmaceutical Company Ltd 78

Table 89: Influenza A Virus, H1N1 Subtype Infections – Pipeline by TechnoVax Inc 78

Table 90: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Touchlight Genetics Ltd 78

Table 91: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Vaccibody AS 79

Table 92: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Vaxart Inc 79

Table 93: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Vironova AB 80

Table 94: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Visterra Inc 80

Table 95: Influenza A Virus, H5N1 Subtype Infections – Dormant Projects 81

Table 96: Influenza A Virus, H1N1 Subtype Infections – Dormant Projects 86

Table 97: Influenza A Virus, H5N1 Subtype Infections – Discontinued Products 90

Table 98: Influenza A Virus, H1N1 Subtype Infections – Discontinued Products 90

List of Figures

1.2 List of Figures

Figure 1: Number of Products under Development for Influenza A Virus, H5N1 Subtype Infections 9

Figure 2: Number of Products under Development by Companies Influenza A Virus, H5N1 Subtype Infections 10

Figure 3: Number of Products under Development by Universities/Institutes Influenza A Virus, H5N1 Subtype Infections 13

Figure 4: Number of Products under Development for Influenza A Virus, H1N1 Subtype Infections 18

Figure 5: Number of Products under Development by Companies Influenza A Virus, H1N1 Subtype Infections 19

Figure 6: Number of Products under Development by Universities/Institutes Influenza A Virus, H1N1 Subtype Infections 22

Figure 7: Number of Products by Top 10 Targets Influenza A Virus, H5N1 Subtype Infections 30

Figure 8: Number of Products by Stage and Top 10 Targets Influenza A Virus, H5N1 Subtype Infections 30

Figure 9: Number of Products by Top 10 Mechanism of Actions Influenza A Virus, H5N1 Subtype Infections 31

Figure 10: Number of Products by Stage and Top 10 Mechanism of Actions Influenza A Virus, H5N1 Subtype Infections 32

Figure 11: Number of Products by Top 10 Routes of Administration Influenza A Virus, H5N1 Subtype Infections 33

Figure 12: Number of Products by Stage and Top 10 Routes of Administration Influenza A Virus, H5N1 Subtype Infections 33

Figure 13: Number of Products by Top 10 Molecule Types Influenza A Virus, H5N1 Subtype Infections 34

Figure 14: Number of Products by Stage and Top 10 Molecule Types Influenza A Virus, H5N1 Subtype Infections 35

Figure 15: Number of Products by Top 10 Targets Influenza A Virus, H1N1 Subtype Infections 36

Figure 16: Number of Products by Stage and Top 10 Targets Influenza A Virus, H1N1 Subtype Infections 36

Figure 17: Number of Products by Top 10 Mechanism of Actions Influenza A Virus, H1N1 Subtype Infections 38

Figure 18: Number of Products by Stage and Top 10 Mechanism of Actions Influenza A Virus, H1N1 Subtype Infections 38

Figure 19: Number of Products by Top 10 Routes of Administration Influenza A Virus, H1N1 Subtype Infections 40

Figure 20: Number of Products by Stage and Top 10 Routes of Administration Influenza A Virus, H1N1 Subtype Infections 40

Figure 21: Number of Products by Top 10 Molecule Types Influenza A Virus, H1N1 Subtype Infections 41

Figure 22: Number of Products by Stage and Top 10 Molecule Types Influenza A Virus, H1N1 Subtype Infections 42

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