Colorectal Cancer Drug Development Pipeline Review, 2017

Pages: 299
Published: September 2017
Report Code: GBIHC019IDB
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This report provides an overview of the colorectal cancer pipeline landscape. The report provides comprehensive information on the therapeutics under development and key players involved in therapeutic development for anal, rectal and colorectal cancer, and features dormant and discontinued projects.

Anal cancer starts in the anus. Symptoms include rectal bleeding, rectal itching, a lump or mass at the anal opening, pain or a feeling of fullness in the anal area, narrowing of stool, pain or a feeling of fullness in the anal area

Rectal cancer affects the lower part of the colon, which connects the large bowel to the anus. The common signs and symptoms of rectal cancer include a change in bowel habits, diarrhea, constipation, or feeling that the bowel does not empty completely, blood, either bright red or very dark in the stool, stools that are narrower than usual, general abdominal discomfort such as frequent gas pains, bloating, fullness or cramps, weight loss with no known reason, constant tiredness and vomiting.

Finally, colorectal cancer is a cancer that starts in the colon or the rectum. Colorectal cancers begin as a growth called a polyp on the inner lining of the colon or rectum. Symptoms include abdominal pain and tenderness in the lower abdomen, blood in the stool, diarrhea, constipation, change in bowel habits, narrow stools and weight loss with no known reason.

The size of these pipelines ranges from 10 products in rectal cancer to 581 products in colorectal cancer. Across all three of these indications, however, kinases, immune-related proteins, DNA-related proteins and viral proteins are common targets, closely reflecting the current treatment landscape of these diseases.

Scope

– Which companies are the most active within the pipeline for colorectal cancer therapeutics?

– Which pharmaceutical approaches are the most prominent at each stage of the pipeline and within each indication?

– To what extent do universities and institutions play a role within this pipeline, compared to pharmaceutical companies?

– What are the most important R&D milestones and data publications to have happened in the field of colorectal cancer?

Reasons to buy

- Understand the overall pipeline, with an at-a-glance overview of all products in therapeutic development for each indication

- Assess the products in development in granular detail, with an up-to-date overview of each individual pipeline program in each indication, and a comprehensive picture of recent updates and milestones for each

- Analyze the companies, institutions and universities currently operating in the pipeline, and the products being fielded by each of these

- Understand the composition of the pipeline in terms of molecule type, molecular target, mechanism of action and route of administration

1 Table of Contents

1 Table of Contents 4

1.1 List of Tables 5

1.2 List of Figures 10

2 Introduction 11

2.1 Colorectal Cancer Report Coverage 11

2.2 Anal Cancer - Overview 11

2.3 Rectal Cancer - Overview 11

2.4 Colorectal Cancer - Overview 11

3 Therapeutics Development 12

3.1 Anal Cancer 12

3.2 Rectal Cancer 16

3.3 Colorectal Cancer 18

4 Therapeutics Assessment 56

4.1 Anal Cancer 56

4.2 Rectal Cancer 63

4.3 Colorectal Cancer 71

5 Companies Involved in Therapeutics Development 100

5.1 Anal Cancer 100

5.2 Rectal Cancer 108

5.3 Colorectal Cancer 114

6 Dormant Projects 241

6.1 Anal Cancer 241

6.2 Rectal Cancer 241

6.3 Colorectal Cancer 242

7 Discontinued Products 261

7.1 Anal Cancer 261

7.2 Colorectal Cancer 261

8 Product Development Milestones 265

8.1 Anal Cancer 265

8.2 Rectal Cancer 278

8.3 Colorectal Cancer 280

9 Appendix 298

9.1 Methodology 298

9.2 Coverage 298

9.3 Secondary Research 298

9.4 Primary Research 298

9.5 Expert Panel Validation 298

9.6 Contact Us 299

9.7 Disclaimer 299

List of Tables

1.1 List of Tables

Table 1: Number of Products under Development for Anal Cancer 12

Table 2: Number of Products under Development by Companies Anal Cancer 14

Table 3: Products under Development by Companies Anal Cancer 15

Table 4: Number of Products under Development for Rectal Cancer 16

Table 5: Number of Products under Development by Companies Rectal Cancer 17

Table 6: Products under Development by Companies Rectal Cancer 18

Table 7: Number of Products under Development by Companies Colorectal Cancer 21

Table 8: Number of Products under Development by Universities/Institutes Colorectal Cancer 30

Table 9: Products under Development by Companies Colorectal Cancer 32

Table 10: Products under Development by Universities/Institutes Colorectal Cancer 52

Table 11: Number of Products by Stage and Target Anal Cancer 57

Table 12: Number of Products by Stage and Mechanism of Action Anal Cancer 59

Table 13: Number of Products by Stage and Route of Administration Anal Cancer 61

Table 14: Number of Products by Stage and Molecule Type Anal Cancer 63

Table 15: Number of Products by Stage and Target Rectal Cancer 65

Table 16: Number of Products by Stage and Mechanism of Action Rectal Cancer 67

Table 17: Number of Products by Stage and Route of Administration Rectal Cancer 69

Table 18: Number of Products by Stage and Molecule Type Rectal Cancer 71

Table 19: Number of Products by Stage and Target Colorectal Cancer 73

Table 20: Number of Products by Stage and Mechanism of Action Colorectal Cancer 87

Table 21: Number of Products by Stage and Route of Administration Colorectal Cancer 97

Table 22: Number of Products by Stage and Molecule Type Colorectal Cancer 99

Table 23: Anal Cancer – Pipeline by Advaxis Inc 100

Table 24: Anal Cancer – Pipeline by Amgen Inc 101

Table 25: Anal Cancer – Pipeline by Atara Biotherapeutics Inc 101

Table 26: Anal Cancer – Pipeline by Bayer AG 102

Table 27: Anal Cancer – Pipeline by BeiGene Ltd 102

Table 28: Anal Cancer – Pipeline by Eli Lilly and Company 103

Table 29: Anal Cancer – Pipeline by Immunovaccine Inc 103

Table 30: Anal Cancer – Pipeline by ISA Pharmaceuticals BV 104

Table 31: Anal Cancer – Pipeline by Merck & Co Inc 105

Table 32: Anal Cancer – Pipeline by Ono Pharmaceutical Co Ltd 106

Table 33: Anal Cancer – Pipeline by Oryx GmbH & Co KG 106

Table 34: Anal Cancer – Pipeline by PDS Biotechnology Corp 106

Table 35: Anal Cancer – Pipeline by Sun Pharma Advanced Research Company Ltd 107

Table 36: Anal Cancer – Pipeline by Taiwan Liposome Company Ltd 108

Table 37: Rectal Cancer – Pipeline by AbbVie Inc 108

Table 38: Rectal Cancer – Pipeline by Advaxis Inc 109

Table 39: Rectal Cancer – Pipeline by Eisai Co Ltd 109

Table 40: Rectal Cancer – Pipeline by GlaxoSmithKline Plc 110

Table 41: Rectal Cancer – Pipeline by Karyopharm Therapeutics Inc 111

Table 42: Rectal Cancer – Pipeline by Madrigal Pharmaceuticals Inc. 111

Table 43: Rectal Cancer – Pipeline by NewLink Genetics Corp 112

Table 44: Rectal Cancer – Pipeline by Peregrine Pharmaceuticals Inc 113

Table 45: Rectal Cancer – Pipeline by Regeneron Pharmaceuticals Inc 113

Table 46: Rectal Cancer – Pipeline by Taiwan Liposome Company Ltd 114

Table 47: Colorectal Cancer – Pipeline by 2cureX ApS 114

Table 48: Colorectal Cancer – Pipeline by 3-V Biosciences Inc 115

Table 49: Colorectal Cancer – Pipeline by 3SBio Inc 115

Table 50: Colorectal Cancer – Pipeline by 4SC AG 116

Table 51: Colorectal Cancer – Pipeline by AB Science SA 116

Table 52: Colorectal Cancer – Pipeline by AbbVie Inc 117

Table 53: Colorectal Cancer – Pipeline by AbGenomics International Inc 118

Table 54: Colorectal Cancer – Pipeline by Aclaris Therapeutics Inc 118

Table 55: Colorectal Cancer – Pipeline by Adamed Sp z oo 119

Table 56: Colorectal Cancer – Pipeline by Aduro BioTech Inc 119

Table 57: Colorectal Cancer – Pipeline by Advenchen Laboratories LLC 120

Table 58: Colorectal Cancer – Pipeline by Allinky Biopharma 120

Table 59: Colorectal Cancer – Pipeline by amcure GmbH 121

Table 60: Colorectal Cancer – Pipeline by Amgen Inc 121

Table 61: Colorectal Cancer – Pipeline by Antibe Therapeutics Inc 122

Table 62: Colorectal Cancer – Pipeline by APEIRON Biologics AG 122

Table 63: Colorectal Cancer – Pipeline by Apexigen Inc 123

Table 64: Colorectal Cancer – Pipeline by Aphios Corp 123

Table 65: Colorectal Cancer – Pipeline by Aposense Ltd 124

Table 66: Colorectal Cancer – Pipeline by ARMO Biosciences Inc 124

Table 67: Colorectal Cancer – Pipeline by ArQule Inc 125

Table 68: Colorectal Cancer – Pipeline by Array BioPharma Inc 125

Table 69: Colorectal Cancer – Pipeline by Asana BioSciences LLC 126

Table 70: Colorectal Cancer – Pipeline by Aslan Pharmaceuticals Pte Ltd 126

Table 71: Colorectal Cancer – Pipeline by Astellas Pharma Inc 127

Table 72: Colorectal Cancer – Pipeline by Astex Pharmaceuticals Inc 127

Table 73: Colorectal Cancer – Pipeline by AstraZeneca Plc 128

Table 74: Colorectal Cancer – Pipeline by Aurobindo Pharma Ltd 129

Table 75: Colorectal Cancer – Pipeline by AVEO Pharmaceuticals Inc 129

Table 76: Colorectal Cancer – Pipeline by B Cell Design SAS 130

Table 77: Colorectal Cancer – Pipeline by Basilea Pharmaceutica Ltd 130

Table 78: Colorectal Cancer – Pipeline by Bavarian Nordic A/S 131

Table 79: Colorectal Cancer – Pipeline by Bayer AG 132

Table 80: Colorectal Cancer – Pipeline by BeiGene Ltd 132

Table 81: Colorectal Cancer – Pipeline by Beijing Hanmi Pharmaceutical Co Ltd 133

Table 82: Colorectal Cancer – Pipeline by BeyondSpring Pharmaceuticals Inc 133

Table 83: Colorectal Cancer – Pipeline by Biocon Ltd 134

Table 84: Colorectal Cancer – Pipeline by Bionomics Ltd 134

Table 85: Colorectal Cancer – Pipeline by Bionovis SA 135

Table 86: Colorectal Cancer – Pipeline by Biotecnol Ltd 135

Table 87: Colorectal Cancer – Pipeline by Biothera Pharmaceutical Inc 136

Table 88: Colorectal Cancer – Pipeline by Boehringer Ingelheim GmbH 137

Table 89: Colorectal Cancer – Pipeline by Boston Biomedical Inc 137

Table 90: Colorectal Cancer – Pipeline by Bristol-Myers Squibb Company 138

Table 91: Colorectal Cancer – Pipeline by Calithera Biosciences Inc 138

Table 92: Colorectal Cancer – Pipeline by Cancer Prevention Pharmaceuticals Inc 139

Table 93: Colorectal Cancer – Pipeline by Cantargia AB 139

Table 94: Colorectal Cancer – Pipeline by Carna Biosciences Inc 140

Table 95: Colorectal Cancer – Pipeline by Cascadian Therapeutics Inc 141

Table 96: Colorectal Cancer – Pipeline by CBT Pharmaceuticals Inc 141

Table 97: Colorectal Cancer – Pipeline by CCRP Therapeutics GmbH 141

Table 98: Colorectal Cancer – Pipeline by Celgene Corp 142

Table 99: Colorectal Cancer – Pipeline by Celldex Therapeutics Inc 143

Table 100: Colorectal Cancer – Pipeline by Cellectar Biosciences Inc 143

Table 101: Colorectal Cancer – Pipeline by Celleron Therapeutics Ltd 144

Table 102: Colorectal Cancer – Pipeline by Celltrion Inc 144

Table 103: Colorectal Cancer – Pipeline by Celyad SA 145

Table 104: Colorectal Cancer – Pipeline by Chipscreen Biosciences Ltd 145

Table 105: Colorectal Cancer – Pipeline by ChoDang Pharm Co Ltd 146

Table 106: Colorectal Cancer – Pipeline by Chong Kun Dang Pharmaceutical Corp 146

Table 107: Colorectal Cancer – Pipeline by Cleave Biosciences Inc 147

Table 108: Colorectal Cancer – Pipeline by Cleveland BioLabs Inc 147

Table 109: Colorectal Cancer – Pipeline by COARE Biotechnology Inc 148

Table 110: Colorectal Cancer – Pipeline by Coherus BioSciences Inc 149

Table 111: Colorectal Cancer – Pipeline by Compugen Ltd 149

Table 112: Colorectal Cancer – Pipeline by Conatus Pharmaceuticals Inc 150

Table 113: Colorectal Cancer – Pipeline by Corvus Pharmaceuticals Inc 150

Table 114: Colorectal Cancer – Pipeline by Critical Outcome Technologies Inc 151

Table 115: Colorectal Cancer – Pipeline by CrystalGenomics Inc 151

Table 116: Colorectal Cancer – Pipeline by Daiichi Sankyo Company Ltd 152

Table 117: Colorectal Cancer – Pipeline by DanDrit Biotech A/S 152

Table 118: Colorectal Cancer – Pipeline by Deciphera Pharmaceuticals LLC 153

Table 119: Colorectal Cancer – Pipeline by Dr. Reddy’s Laboratories Ltd 153

Table 120: Colorectal Cancer – Pipeline by eFFECTOR Therapeutics Inc 154

Table 121: Colorectal Cancer – Pipeline by Eisai Co Ltd 154

Table 122: Colorectal Cancer – Pipeline by Eli Lilly and Co 155

Table 123: Colorectal Cancer – Pipeline by Endor Nanotechnologies SL 155

Table 124: Colorectal Cancer – Pipeline by Ensol Biosciences Inc 156

Table 125: Colorectal Cancer – Pipeline by EntreChem SL 156

Table 126: Colorectal Cancer – Pipeline by Enzene Biosciences Ltd 157

Table 127: Colorectal Cancer – Pipeline by Enzo Biochem Inc 157

Table 128: Colorectal Cancer – Pipeline by EpiThany Inc 158

Table 129: Colorectal Cancer – Pipeline by Etubics Corp 158

Table 130: Colorectal Cancer – Pipeline by Exelixis Inc 159

Table 131: Colorectal Cancer – Pipeline by Exicure Inc 159

Table 132: Colorectal Cancer – Pipeline by F-star Biotechnology Ltd 160

Table 133: Colorectal Cancer – Pipeline by F. Hoffmann-La Roche Ltd 160

Table 134: Colorectal Cancer – Pipeline by Formosa Laboratories Inc 161

Table 135: Colorectal Cancer – Pipeline by Forty Seven Inc 161

Table 136: Colorectal Cancer – Pipeline by Fusion Antibodies Ltd 162

Table 137: Colorectal Cancer – Pipeline by Gene Techno Science Co Ltd 162

Table 138: Colorectal Cancer – Pipeline by Genentech Inc 163

Table 139: Colorectal Cancer – Pipeline by Genor BioPharma Co Ltd 163

Table 140: Colorectal Cancer – Pipeline by Genoscience Pharma 164

Table 141: Colorectal Cancer – Pipeline by Genzyme Corp 164

Table 142: Colorectal Cancer – Pipeline by Gilead Sciences Inc 165

Table 143: Colorectal Cancer – Pipeline by GlaxoSmithKline Plc 166

Table 144: Colorectal Cancer – Pipeline by Glenmark Pharmaceuticals Ltd 166

Table 145: Colorectal Cancer – Pipeline by Glycostem Therapeutics BV 167

Table 146: Colorectal Cancer – Pipeline by Glycotope GmbH 167

Table 147: Colorectal Cancer – Pipeline by Green Cross Corp 168

Table 148: Colorectal Cancer – Pipeline by Handok Inc 168

Table 149: Colorectal Cancer – Pipeline by Hanmi Pharmaceuticals Co Ltd 169

Table 150: Colorectal Cancer – Pipeline by Heat Biologics Inc 169

Table 151: Colorectal Cancer – Pipeline by Hemispherx Biopharma Inc 170

Table 152: Colorectal Cancer – Pipeline by Humanigen Inc 170

Table 153: Colorectal Cancer – Pipeline by Humorigin Biotechnology Corp 171

Table 154: Colorectal Cancer – Pipeline by Hutchison MediPharma Ltd 171

Table 155: Colorectal Cancer – Pipeline by iDD biotech SAS 172

Table 156: Colorectal Cancer – Pipeline by Ideaya Biosciences Inc 172

Table 157: Colorectal Cancer – Pipeline by Ignyta Inc 172

Table 158: Colorectal Cancer – Pipeline by Ildong Pharmaceutical Co Ltd 173

Table 159: Colorectal Cancer – Pipeline by Immodulon Therapeutics Ltd 173

Table 160: Colorectal Cancer – Pipeline by ImmuneXcite Inc 174

Table 161: Colorectal Cancer – Pipeline by Immunomedics Inc 175

Table 162: Colorectal Cancer – Pipeline by Immunovative Therapies Ltd 175

Table 163: Colorectal Cancer – Pipeline by Incanthera Ltd 176

Table 164: Colorectal Cancer – Pipeline by Incyte Corp 176

Table 165: Colorectal Cancer – Pipeline by Innovation Pharmaceuticals Inc 177

Table 166: Colorectal Cancer – Pipeline by Innovent Biologics Inc 177

Table 167: Colorectal Cancer – Pipeline by Inovio Pharmaceuticals Inc 178

Table 168: Colorectal Cancer – Pipeline by Interprotein Corp 178

Table 169: Colorectal Cancer – Pipeline by Intezyne Technologies Inc 179

Table 170: Colorectal Cancer – Pipeline by Ionis Pharmaceuticals Inc 179

Table 171: Colorectal Cancer – Pipeline by Isofol Medical AB 180

Table 172: Colorectal Cancer – Pipeline by Jeil Pharmaceutical Co Ltd 180

Table 173: Colorectal Cancer – Pipeline by JHL Biotech Inc 181

Table 174: Colorectal Cancer – Pipeline by Jiangsu Hengrui Medicine Co Ltd 182

Table 175: Colorectal Cancer – Pipeline by Johnson & Johnson 182

Table 176: Colorectal Cancer – Pipeline by Kancera AB 183

Table 177: Colorectal Cancer – Pipeline by Karyopharm Therapeutics Inc 183

Table 178: Colorectal Cancer – Pipeline by Kura Oncology Inc 184

Table 179: Colorectal Cancer – Pipeline by Laboratorio ELEA SACIF y A 184

Table 180: Colorectal Cancer – Pipeline by LipoMedix Pharmaceutical Inc 185

Table 181: Colorectal Cancer – Pipeline by Loxo Oncology Inc 185

Table 182: Colorectal Cancer – Pipeline by Luye Pharma Group Ltd 186

Table 183: Colorectal Cancer – Pipeline by Mabion SA 187

Table 184: Colorectal Cancer – Pipeline by MacroGenics Inc 187

Table 185: Colorectal Cancer – Pipeline by Mantis Therapeutics BV 188

Table 186: Colorectal Cancer – Pipeline by Marina Biotech Inc 188

Table 187: Colorectal Cancer – Pipeline by Medesis Pharma SA 189

Table 188: Colorectal Cancer – Pipeline by MediaPharma SRL 189

Table 189: Colorectal Cancer – Pipeline by MedImmune LLC 189

Table 190: Colorectal Cancer – Pipeline by Medinet Co Ltd 190

Table 191: Colorectal Cancer – Pipeline by Medivir AB 191

Table 192: Colorectal Cancer – Pipeline by Merck & Co Inc 191

Table 193: Colorectal Cancer – Pipeline by Merck KGaA 192

Table 194: Colorectal Cancer – Pipeline by Merrimack Pharmaceuticals Inc 193

Table 195: Colorectal Cancer – Pipeline by Merus NV 193

Table 196: Colorectal Cancer – Pipeline by Microlin Bio Inc 194

Table 197: Colorectal Cancer – Pipeline by Millennium Pharmaceuticals Inc 194

Table 198: Colorectal Cancer – Pipeline by Molecular Partners AG 195

Table 199: Colorectal Cancer – Pipeline by MolMed SpA 195

Table 200: Colorectal Cancer – Pipeline by Mologen AG 196

Table 201: Colorectal Cancer – Pipeline by Morphotek Inc 196

Table 202: Colorectal Cancer – Pipeline by Multimmune GmbH 197

Table 203: Colorectal Cancer – Pipeline by Mycenax Biotech Inc 197

Table 204: Colorectal Cancer – Pipeline by NantKwest Inc 198

Table 205: Colorectal Cancer – Pipeline by Natco Pharma Ltd 198

Table 206: Colorectal Cancer – Pipeline by NatureWise Biotech & Medicals Corp 199

Table 207: Colorectal Cancer – Pipeline by Nektar Therapeutics 200

Table 208: Colorectal Cancer – Pipeline by Neovacs SA 200

Table 209: Colorectal Cancer – Pipeline by Nerviano Medical Sciences Srl 201

Table 210: Colorectal Cancer – Pipeline by Nippon Kayaku Co Ltd 201

Table 211: Colorectal Cancer – Pipeline by NormOxys Inc 202

Table 212: Colorectal Cancer – Pipeline by Northwest Biotherapeutics Inc 202

Table 213: Colorectal Cancer – Pipeline by Novartis AG 203

Table 214: Colorectal Cancer – Pipeline by Novogen Ltd 204

Table 215: Colorectal Cancer – Pipeline by Noxxon Pharma AG 204

Table 216: Colorectal Cancer – Pipeline by NuCana BioMed Ltd 205

Table 217: Colorectal Cancer – Pipeline by OBI Pharma Inc 205

Table 218: Colorectal Cancer – Pipeline by Omnitura Therapeutics Inc 205

Table 219: Colorectal Cancer – Pipeline by Oncobiologics Inc 206

Table 220: Colorectal Cancer – Pipeline by Oncology Research International Ltd 206

Table 221: Colorectal Cancer – Pipeline by Oncolytics Biotech Inc 207

Table 222: Colorectal Cancer – Pipeline by OncoMed Pharmaceuticals Inc 208

Table 223: Colorectal Cancer – Pipeline by Onconova Therapeutics Inc 208

Table 224: Colorectal Cancer – Pipeline by Ono Pharmaceutical Co Ltd 209

Table 225: Colorectal Cancer – Pipeline by Oryx GmbH & Co KG 209

Table 226: Colorectal Cancer – Pipeline by Otsuka Holdings Co Ltd 210

Table 227: Colorectal Cancer – Pipeline by Oxford BioMedica Plc 210

Table 228: Colorectal Cancer – Pipeline by Pfizer Inc 211

Table 229: Colorectal Cancer – Pipeline by Pharma Mar SA 212

Table 230: Colorectal Cancer – Pipeline by PharmAbcine Inc 212

Table 231: Colorectal Cancer – Pipeline by Pivotal BioSciences Inc 212

Table 232: Colorectal Cancer – Pipeline by PlantForm Corp 213

Table 233: Colorectal Cancer – Pipeline by Plexxikon Inc 213

Table 234: Colorectal Cancer – Pipeline by PLx Pharma Inc 214

Table 235: Colorectal Cancer – Pipeline by Precision Biologics Inc 214

Table 236: Colorectal Cancer – Pipeline by Propanac Biopharma Inc 214

Table 237: Colorectal Cancer – Pipeline by Provectus Biopharmaceuticals Inc 215

Table 238: Colorectal Cancer – Pipeline by PsiOxus Therapeutics Ltd 216

Table 239: Colorectal Cancer – Pipeline by Puma Biotechnology Inc 216

Table 240: Colorectal Cancer – Pipeline by Puretech Health plc 217

Table 241: Colorectal Cancer – Pipeline by R Pharm 217

Table 242: Colorectal Cancer – Pipeline by Rafael Pharmaceuticals Inc 217

Table 243: Colorectal Cancer – Pipeline by RedHill Biopharma Ltd 218

Table 244: Colorectal Cancer – Pipeline by Redx Pharma Plc 218

Table 245: Colorectal Cancer – Pipeline by Rexahn Pharmaceuticals Inc 219

Table 246: Colorectal Cancer – Pipeline by Rgenix Inc 219

Table 247: Colorectal Cancer – Pipeline by Rhizen Pharmaceuticals SA 220

Table 248: Colorectal Cancer – Pipeline by Richter Gedeon Nyrt 220

Table 249: Colorectal Cancer – Pipeline by Samumed LLC 221

Table 250: Colorectal Cancer – Pipeline by Sanofi 221

Table 251: Colorectal Cancer – Pipeline by Selvita SA 222

Table 252: Colorectal Cancer – Pipeline by Siamab Therapeutics Inc 222

Table 253: Colorectal Cancer – Pipeline by Sichuan Kelun Pharmaceutical Co Ltd 223

Table 254: Colorectal Cancer – Pipeline by Sigma-Tau SpA 223

Table 255: Colorectal Cancer – Pipeline by Sigmoid Pharma Ltd 224

Table 256: Colorectal Cancer – Pipeline by Sillajen Biotherapeutics 224

Table 257: Colorectal Cancer – Pipeline by Simcere Pharmaceutical Group 225

Table 258: Colorectal Cancer – Pipeline by Sorrento Therapeutics Inc 225

Table 259: Colorectal Cancer – Pipeline by Steba Biotech SA 226

Table 260: Colorectal Cancer – Pipeline by Sumitomo Dainippon Pharma Co Ltd 226

Table 261: Colorectal Cancer – Pipeline by SuviCa Inc 227

Table 262: Colorectal Cancer – Pipeline by Symphogen A/S 227

Table 263: Colorectal Cancer – Pipeline by SynDevRx Inc 228

Table 264: Colorectal Cancer – Pipeline by Synermore Biologics Co Ltd 228

Table 265: Colorectal Cancer – Pipeline by Taiho Pharmaceutical Co Ltd 228

Table 266: Colorectal Cancer – Pipeline by TaiwanJ Pharmaceuticals Co Ltd 229

Table 267: Colorectal Cancer – Pipeline by Takeda Pharmaceutical Co Ltd 230

Table 268: Colorectal Cancer – Pipeline by Targovax ASA 230

Table 269: Colorectal Cancer – Pipeline by Tarrex Biopharma Ltd 231

Table 270: Colorectal Cancer – Pipeline by Tarveda Therapeutics Inc 231

Table 271: Colorectal Cancer – Pipeline by tella Inc 232

Table 272: Colorectal Cancer – Pipeline by Tiltan Pharma Ltd 232

Table 273: Colorectal Cancer – Pipeline by Tocagen Inc 232

Table 274: Colorectal Cancer – Pipeline by TRACON Pharmaceuticals Inc 233

Table 275: Colorectal Cancer – Pipeline by Transgene SA 233

Table 276: Colorectal Cancer – Pipeline by United BioPharma Inc 234

Table 277: Colorectal Cancer – Pipeline by Vaccinex Inc 234

Table 278: Colorectal Cancer – Pipeline by VasGene Therapeutics Inc 235

Table 279: Colorectal Cancer – Pipeline by Vaximm AG 235

Table 280: Colorectal Cancer – Pipeline by ViiV Healthcare Ltd 235

Table 281: Colorectal Cancer – Pipeline by Vitality Biopharma Inc 236

Table 282: Colorectal Cancer – Pipeline by Wellstat Biologics Corp 236

Table 283: Colorectal Cancer – Pipeline by Wilex AG 237

Table 284: Colorectal Cancer – Pipeline by WntResearch AB 237

Table 285: Colorectal Cancer – Pipeline by Wuhan YZY Biopharma Co Ltd 238

Table 286: Colorectal Cancer – Pipeline by XBiotech Inc 238

Table 287: Colorectal Cancer – Pipeline by XuanZhu Pharma Co Ltd 239

Table 288: Colorectal Cancer – Pipeline by Yabao Pharmaceutical Group Co Ltd 239

Table 289: Colorectal Cancer – Pipeline by Zymeworks Inc 240

Table 290: Anal Cancer – Dormant Projects 241

Table 291: Rectal Cancer – Dormant Projects 241

Table 292: Colorectal Cancer – Dormant Projects 242

Table 293: Anal Cancer – Discontinued Products 261

Table 294: Colorectal Cancer – Discontinued Products 261

List of Figures

1.2 List of Figures

Figure 1: Number of Products under Development for Anal Cancer 12

Figure 2: Number of Products under Development by Companies Anal Cancer 13

Figure 3: Number of Products under Development for Rectal Cancer 16

Figure 4: Number of Products under Development by Companies Rectal Cancer 17

Figure 5: Number of Products under Development for Colorectal Cancer 18

Figure 6: Number of Products under Development by Companies Colorectal Cancer 20

Figure 7: Number of Products under Development by Universities/Institutes Colorectal Cancer 30

Figure 8: Number of Products by Top 10 Targets Anal Cancer 56

Figure 9: Number of Products by Stage and Top 10 Targets Anal Cancer 56

Figure 10: Number of Products by Top 10 Mechanism of Actions Anal Cancer 58

Figure 11: Number of Products by Stage and Top 10 Mechanism of Actions Anal Cancer 58

Figure 12: Number of Products by Routes of Administration Anal Cancer 60

Figure 13: Number of Products by Stage and Routes of Administration Anal Cancer 60

Figure 14: Number of Products by Molecule Types Anal Cancer 62

Figure 15: Number of Products by Stage and Molecule Types Anal Cancer 62

Figure 16: Number of Products by Top 10 Targets Rectal Cancer 63

Figure 17: Number of Products by Stage and Top 10 Targets Rectal Cancer 64

Figure 18: Number of Products by Top 10 Mechanism of Actions Rectal Cancer 66

Figure 19: Number of Products by Stage and Top 10 Mechanism of Actions Rectal Cancer 66

Figure 20: Number of Products by Routes of Administration Rectal Cancer 68

Figure 21: Number of Products by Stage and Routes of Administration Rectal Cancer 68

Figure 22: Number of Products by Molecule Types Rectal Cancer 70

Figure 23: Number of Products by Stage and Molecule Types Rectal Cancer 70

Figure 24: Number of Products by Top 10 Targets Colorectal Cancer 71

Figure 25: Number of Products by Stage and Top 10 Targets Colorectal Cancer 72

Figure 26: Number of Products by Top 10 Mechanism of Actions Colorectal Cancer 86

Figure 27: Number of Products by Stage and Top 10 Mechanism of Actions Colorectal Cancer 86

Figure 28: Number of Products by Routes of Administration Colorectal Cancer 96

Figure 29: Number of Products by Stage and Routes of Administration Colorectal Cancer 96

Figure 30: Number of Products by Top 10 Molecule Types Colorectal Cancer 98

Figure 31: Number of Products by Stage and Top 10 Molecule Types Colorectal Cancer 98

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