CNS Cluster Addiction Drug Development Pipeline Review, 2017

The central nervous system (CNS) addiction cluster report provides an overview of the CNS Clusters pipeline landscape. The report provides comprehensive information on the therapeutics under development, and key players involved in therapeutic development for Alcohol Addiction, Drug Addiction, Nicotine Addiction, Opium (Opioid) Addiction and features dormant and discontinued projects.

Alcohol addiction refers to a psychological and physical dependency on alcohol. Symptoms include decreased involvement in extracurricular activities, depression, restlessness, inability to control drinking and violent behavior. Drug addiction, also called substance dependence or chemical dependency, is a disease that is characterized by a destructive pattern of drug abuse that leads to significant problems involving tolerance to or withdrawal from the substance. Nicotine addiction also called tobacco dependence is an addiction to tobacco products caused by the drug nicotine. Finally, opioid addiction develops after using opioids regularly for a period of time. Prolonged use of opiates can lead to nerve damage within the brain that causes cells to stop producing endogenous opiates (natural painkillers known as endorphins).

The size of these pipelines ranges from 19 in nicotine addiction to 67 in drug addiction, with a substantial degree of overlap between these indications in terms of the key players and the types of molecular target which are being studied. The mu and kappa-opioid receptors are the dominant molecular target across alcohol, drug and opioid addiction, and other neurotransmitter receptors such as the cannabinoid and dopamine receptors are common molecular targets across the three.

Scope

– Which companies are the most active within the pipeline for addiction therapeutics?

– Which pharmaceutical approaches are the most prominent at each stage of the pipeline and within each indication?

– To what extent do universities and institutions play a role within this pipeline, compared to pharmaceutical companies?

– What are the most important R&D milestones and data publications to have happened in the field of addiction therapeutics?

Reasons to buy

- Understand the overall pipeline, with an at-a-glance overview of all products in therapeutic development for each indication

- Assess the products in development in granular detail, with an up-to-date overview of each individual pipeline program in each indication, and a comprehensive picture of recent updates and milestones for each

- Analyze the companies, institutions and universities currently operating in the pipeline, and the products being fielded by each of these

- Understand the composition of the pipeline in terms of molecule type, molecular target, mechanism of action and route of administration

Table of Contents

Table of Contents

GBI Research Report Guidance 2

Executive Summary 3

Table of Contents 4

List of Tables 6

List of Figures 9

Introduction 10

CNS Cluster Addiction Report Coverage 10

Alcohol Addiction – Overview 10

Drug Addiction – Overview 10

Nicotine Addiction – Overview 10

Opium (Opioid) Addiction – Overview 10

Therapeutics Development 11

Alcohol Addiction 11

Drug Addiction 17

Nicotine Addiction 25

Opium (Opioid) Addiction 28

Therapeutics Assessment 34

Alcohol Addiction 34

Drug Addiction 41

Nicotine Addiction 50

Opium (Opioid) Addiction 56

Companies Involved in Therapeutics Development 65

Alcohol Addiction 65

Drug Addiction 78

Nicotine Addiction 90

Opium (Opioid) Addiction 94

Dormant Projects 104

Alcohol Addiction 104

Drug Addiction 106

Nicotine Addiction 108

Opium (Opioid) Addiction 109

Discontinued Products 110

Alcohol Addiction 110

Drug Addiction 110

Nicotine Addiction 110

Opium (Opioid) Addiction 111

Product Development Milestones 112

Alcohol Addiction 112

Drug Addiction 123

Nicotine Addiction 134

Opium (Opioid) Addiction 137

Appendix 149

Methodology 149

Coverage 149

Secondary Research 149

Primary Research 149

Expert Panel Validation 149

Contact Us 149

Disclaimer 150

List of Tables

List of Tables

Number of Products under Development for Alcohol Addiction 11

Number of Products under Development by Companies, Alcohol Addiction 13

Number of Products under Development by Universities/Institutes, Alcohol Addiction 14

Products under Development by Companies, Alcohol Addiction 15

Products under Development by Universities/Institutes, Alcohol Addiction 16

Number of Products under Development for Drug Addiction 17

Number of Products under Development by Companies, Drug Addiction 19

Number of Products under Development by Universities/Institutes, Drug Addiction 21

Products under Development by Companies, Drug Addiction 22

Products under Development by Universities/Institutes, Drug Addiction 24

Number of Products under Development for Nicotine Addiction 25

Number of Products under Development by Companies, Nicotine Addiction 26

Number of Products under Development by Universities/Institutes, Nicotine Addiction 27

Products under Development by Companies, Nicotine Addiction 27

Products under Development by Universities/Institutes, Nicotine Addiction 28

Number of Products under Development for Opium (Opioid) Addiction 29

Number of Products under Development by Companies, Opium (Opioid) Addiction 30

Number of Products under Development by Universities/Institutes, Opium (Opioid) Addiction 31

Products under Development by Companies, Opium (Opioid) Addiction 32

Products under Development by Universities/Institutes, Opium (Opioid) Addiction 33

Number of Products by Stage and Target, Alcohol Addiction 35

Number of Products by Stage and Mechanism of Action, Alcohol Addiction 37

Number of Products by Stage and Route of Administration, Alcohol Addiction 39

Number of Products by Stage and Molecule Type, Alcohol Addiction 41

Number of Products by Stage and Target, Drug Addiction 43

Number of Products by Stage and Mechanism of Action, Drug Addiction 45

Number of Products by Stage and Route of Administration, Drug Addiction 48

Number of Products by Stage and Molecule Type, Drug Addiction 50

Number of Products by Stage and Target, Nicotine Addiction 51

Number of Products by Stage and Mechanism of Action, Nicotine Addiction 53

Number of Products by Stage and Route of Administration, Nicotine Addiction 54

Number of Products by Stage and Molecule Type, Nicotine Addiction 56

Number of Products by Stage and Target, Opium (Opioid) Addiction 58

Number of Products by Stage and Mechanism of Action, Opium (Opioid) Addiction 60

Number of Products by Stage and Route of Administration, Opium (Opioid) Addiction 62

Number of Products by Stage and Molecule Type, Opium (Opioid) Addiction 64

Alcohol Addiction – Pipeline by AbbVie Inc 65

Alcohol Addiction – Pipeline by Addex Therapeutics Ltd 65

Alcohol Addiction – Pipeline by Adial Pharmaceuticals LLC 66

Alcohol Addiction – Pipeline by Astraea Therapeutics LLC 66

Alcohol Addiction – Pipeline by BioCorRx Inc 67

Alcohol Addiction – Pipeline by Bionex Pharmaceuticals LLC 67

Alcohol Addiction – Pipeline by Bioprojet SCR 68

Alcohol Addiction – Pipeline by Cerecor Inc 68

Alcohol Addiction – Pipeline by Chronos Therapeutics Ltd 69

Alcohol Addiction – Pipeline by Corcept Therapeutics Inc 69

Alcohol Addiction – Pipeline by Curemark LLC 70

Alcohol Addiction – Pipeline by Eli Lilly and Company 70

Alcohol Addiction – Pipeline by Ethypharm SA 71

Alcohol Addiction – Pipeline by Euthymics Bioscience Inc 72

Alcohol Addiction – Pipeline by H. Lundbeck A/S 72

Alcohol Addiction – Pipeline by Heptares Therapeutics Ltd 72

Alcohol Addiction – Pipeline by Indivior Plc 73

Alcohol Addiction – Pipeline by Kinnov Therapeutics SAS 73

Alcohol Addiction – Pipeline by Kyorin Pharmaceutical Co Ltd 74

Alcohol Addiction – Pipeline by Lohocla Research Corp 74

Alcohol Addiction – Pipeline by Omeros Corp 75

Alcohol Addiction – Pipeline by Pfizer Inc 75

Alcohol Addiction – Pipeline by Savant HWP Inc 75

Alcohol Addiction – Pipeline by SK Biopharmaceuticals Co Ltd 76

Alcohol Addiction – Pipeline by Tonix Pharmaceuticals Holding Corp 76

Alcohol Addiction – Pipeline by VM Discovery Inc 77

Alcohol Addiction – Pipeline by XenoPort Inc 77

Alcohol Addiction – Pipeline by Zynerba Pharmaceuticals Inc 78

Drug Addiction – Pipeline by Addex Therapeutics Ltd 78

Drug Addiction – Pipeline by Aelis Farma SAS 79

Drug Addiction – Pipeline by Aphios Corp 79

Drug Addiction – Pipeline by Astraea Therapeutics LLC 79

Drug Addiction – Pipeline by BioCorRx Inc 80

Drug Addiction – Pipeline by Cerecor Inc 80

Drug Addiction – Pipeline by Chiesi Farmaceutici SpA 81

Drug Addiction – Pipeline by Curemark LLC 81

Drug Addiction – Pipeline by Embera NeuroTherapeutics Inc 82

Drug Addiction – Pipeline by F. Hoffmann-La Roche Ltd 82

Drug Addiction – Pipeline by Foresee Pharmaceuticals LLC 83

Drug Addiction – Pipeline by Heptares Therapeutics Ltd 83

Drug Addiction – Pipeline by Immunovaccine Inc 84

Drug Addiction – Pipeline by Indivior Plc 84

Drug Addiction – Pipeline by InterveXion Therapeutics LLC 84

Drug Addiction – Pipeline by Intra-Cellular Therapies Inc 85

Drug Addiction – Pipeline by Kyorin Pharmaceutical Co Ltd 85

Drug Addiction – Pipeline by Kyowa Hakko Kirin Co Ltd 86

Drug Addiction – Pipeline by MedRev Pharma 86

Drug Addiction – Pipeline by NLS Pharma Group 86

Drug Addiction – Pipeline by Omeros Corp 87

Drug Addiction – Pipeline by Opiant Pharmaceuticals Inc 87

Drug Addiction – Pipeline by Orexigen Therapeutics Inc 88

Drug Addiction – Pipeline by P2D Bioscience 88

Drug Addiction – Pipeline by Saniona AB 89

Drug Addiction – Pipeline by Savant HWP Inc 89

Drug Addiction – Pipeline by Stada Arzneimittel AG 89

Drug Addiction – Pipeline by Teva Pharmaceutical Industries Ltd 90

Drug Addiction – Pipeline by Zynerba Pharmaceuticals Inc 90

Nicotine Addiction – Pipeline by Addex Therapeutics Ltd 91

Nicotine Addiction – Pipeline by Astraea Therapeutics LLC 91

Nicotine Addiction – Pipeline by C4X Discovery Holdings PLC 91

Nicotine Addiction – Pipeline by Chronos Therapeutics Ltd 92

Nicotine Addiction – Pipeline by CV Sciences Inc 92

Nicotine Addiction – Pipeline by Hager Biosciences LLC 93

Nicotine Addiction – Pipeline by Heptares Therapeutics Ltd 93

Nicotine Addiction – Pipeline by Omeros Corp 93

Nicotine Addiction – Pipeline by Savant HWP Inc 94

Opium (Opioid) Addiction – Pipeline by Alkermes Plc 94

Opium (Opioid) Addiction – Pipeline by Aoxing Pharmaceutical Company Inc 95

Opium (Opioid) Addiction – Pipeline by Aquilus Pharmaceuticals Inc 95

Opium (Opioid) Addiction – Pipeline by BioCorRx Inc 95

Opium (Opioid) Addiction – Pipeline by BioDelivery Sciences International Inc 96

Opium (Opioid) Addiction – Pipeline by Camurus AB 96

Opium (Opioid) Addiction – Pipeline by Foresee Pharmaceuticals LLC 97

Opium (Opioid) Addiction – Pipeline by Heron Therapeutics Inc 97

Opium (Opioid) Addiction – Pipeline by Indivior Plc 98

Opium (Opioid) Addiction – Pipeline by INSYS Therapeutics Inc 99

Opium (Opioid) Addiction – Pipeline by Omeros Corp 99

Opium (Opioid) Addiction – Pipeline by Opiant Pharmaceuticals Inc 100

Opium (Opioid) Addiction – Pipeline by Orexigen Therapeutics Inc 100

Opium (Opioid) Addiction – Pipeline by Orexo AB 101

Opium (Opioid) Addiction – Pipeline by Pfizer Inc 101

Opium (Opioid) Addiction – Pipeline by Relmada Therapeutics Inc 101

Opium (Opioid) Addiction – Pipeline by Savant HWP Inc 102

Opium (Opioid) Addiction – Pipeline by Teva Pharmaceutical Industries Ltd 102

Opium (Opioid) Addiction – Pipeline by Titan Pharmaceuticals Inc 103

Opium (Opioid) Addiction – Pipeline by Zynerba Pharmaceuticals Inc 103

Alcohol Addiction – Dormant Projects 104

Drug Addiction – Dormant Projects 106

Nicotine Addiction – Dormant Projects 108

Opium (Opioid) Addiction – Dormant Projects 109

Alcohol Addiction – Discontinued Products 110

Drug Addiction – Discontinued Products 110

Nicotine Addiction – Discontinued Products 110

Opium (Opioid) Addiction – Discontinued Products 111

List of Figures

List of Figures

Number of Products under Development for Alcohol Addiction 11

Number of Products under Development by Companies, Alcohol Addiction 12

Number of Products under Development by Universities/Institutes, Alcohol Addiction 14

Number of Products under Development for Drug Addiction 17

Number of Products under Development by Companies, Drug Addiction 18

Number of Products under Development by Universities/Institutes, Drug Addiction 20

Number of Products under Development for Nicotine Addiction 25

Number of Products under Development by Companies, Nicotine Addiction 26

Number of Products under Development for Opium (Opioid) Addiction 28

Number of Products under Development by Companies, Opium (Opioid) Addiction 29

Number of Products under Development by Universities/Institutes, Opium (Opioid) Addiction 31

Number of Products by Top 10 Targets, Alcohol Addiction 34

Number of Products by Stage and Top 10 Targets, Alcohol Addiction 34

Number of Products by Top 10 Mechanism of Actions, Alcohol Addiction 36

Number of Products by Stage and Top 10 Mechanism of Actions, Alcohol Addiction 36

Number of Products by Routes of Administration, Alcohol Addiction 38

Number of Products by Stage and Routes of Administration, Alcohol Addiction 38

Number of Products by Molecule Types, Alcohol Addiction 39

Number of Products by Stage and Molecule Types, Alcohol Addiction 40

Number of Products by Top 10 Targets, Drug Addiction 41

Number of Products by Stage and Top 10 Targets, Drug Addiction 42

Number of Products by Top 10 Mechanism of Actions, Drug Addiction 44

Number of Products by Stage and Top 10 Mechanism of Actions, Drug Addiction 44

Number of Products by Routes of Administration, Drug Addiction 47

Number of Products by Stage and Routes of Administration, Drug Addiction 47

Number of Products by Molecule Types, Drug Addiction 48

Number of Products by Stage and Molecule Types, Drug Addiction 49

Number of Products by Top 10 Targets, Nicotine Addiction 50

Number of Products by Stage and Top 10 Targets, Nicotine Addiction 51

Number of Products by Top 10 Mechanism of Actions, Nicotine Addiction 52

Number of Products by Stage and Top 10 Mechanism of Actions, Nicotine Addiction 52

Number of Products by Stage and Routes of Administration, Nicotine Addiction 54

Number of Products by Molecule Types, Nicotine Addiction 55

Number of Products by Stage and Molecule Types, Nicotine Addiction 55

Number of Products by Top 10 Targets, Opium (Opioid) Addiction 56

Number of Products by Stage and Top 10 Targets, Opium (Opioid) Addiction 57

Number of Products by Top 10 Mechanism of Actions, Opium (Opioid) Addiction 59

Number of Products by Stage and Top 10 Mechanism of Actions, Opium (Opioid) Addiction 59

Number of Products by Routes of Administration, Opium (Opioid) Addiction 61

Number of Products by Stage and Routes of Administration, Opium (Opioid) Addiction 61

Number of Products by Molecule Types, Opium (Opioid) Addiction 63

Number of Products by Stage and Molecule Types, Opium (Opioid) Addiction 63

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