Bladder and Ureter Cancer Drug Development Pipeline Review, 2017

This report provides an overview of the bladder and ureter pipeline landscape. The report provides comprehensive information on the therapeutics under development and key players involved in therapeutic development for these two indications, and features dormant and discontinued projects.

Bladder cancer occurs in tissues of the urinary bladder. Symptoms include blood or blood clots in the urine, frequent urination, lower back pain on one side of the body and burning during urination. There are a total of 223 products in development for this indication, by 158 companies and 19 academic institutions. Key companies active in this space include F. Hoffmann-La Roche, GlaxoSmithKline, AstraZeneca, MedImmune and Pfizer.

Ureter or ureteral cancer affects the ureter, the tube that transports urine from the kidney to the urinary bladder. Symptoms and signs of urethral cancer include bleeding from the urethra or blood in the urine, discharge from the urethra and enlarged lymph nodes in the groin area. This pipeline is far smaller; there are a total of nine products in development for this indication, by six companies and two academic institutions.

Scope

– Which companies are the most active within each pipeline?

– Which pharmaceutical approaches are the most prominent at each stage of the pipeline and within each indication?

– To what extent do universities and institutions play a role within this pipeline, compared to pharmaceutical companies?

– What are the most important R&D milestones and data publications to have happened in this disease area?

Reasons to buy

- Understand the overall pipeline, with an at-a-glance overview of all products in therapeutic development for each indication

- Assess the products in development in granular detail, with an up-to-date overview of each individual pipeline program in each indication, and a comprehensive picture of recent updates and milestones for each

- Analyze the companies, institutions and universities currently operating in the pipeline, and the products being fielded by each of these

- Understand the composition of the pipeline in terms of molecule type, molecular target, mechanism of action and route of administration

Companies mentioned

4SC AG

Abivax SA

Adaptimmune Therapeutics Plc

ADC Therapeutics Sarl

Altor BioScience Corp

AndroScience Corp

ANP Technologies Inc

APIM Therapeutics AS

Archivel Farma SL

Argos Therapeutics Inc

Arno Therapeutics Inc

Array BioPharma Inc

Asana BioSciences LLC

Asieris Pharmaceuticals Co Ltd

Astellas Pharma Inc

Astex Pharmaceuticals Inc

AstraZeneca Plc

AVEO Pharmaceuticals Inc

Bavarian Nordic A/S

Bayer AG

Biocad

BioCancell Ltd

Biohaven Pharmaceutical Holding Company Ltd

Biomics Biotechnologies Co Ltd

Biotest AG

Boehringer Ingelheim GmbH

Bristol-Myers Squibb Co

Celgene Corp

Celldex Therapeutics Inc

Celprogen Inc

Celsion Corp

Celyad SA

Cleveland BioLabs Inc

Cold Genesys Inc

Corvus Pharmaceuticals Inc

CytomX Therapeutics Inc

Cytori Therapeutics Inc

Daiichi Sankyo Co Ltd

Eisai Co Ltd

Eleven Biotherapeutics Inc

Eli Lilly and Co

Elsalys Biotech SAS

EpiThany Inc

Esperance Pharmaceuticals Inc

Exelixis Inc

Exicure Inc

F. Hoffmann-La Roche Ltd

Five Prime Therapeutics Inc

Gene Signal International SA

Genentech Inc

Genmab A/S

GlaxoSmithKline Plc

H3 Biomedicine Inc

Hamlet Pharma AB

Hanmi Pharmaceuticals Co Ltd

HitGen LTD

Horizon Pharma Plc

Immunocore Ltd

Immunomedics Inc

Immupharma Plc

Imugene Ltd

Incanthera Ltd

Incyte Corp

Innovation Pharmaceuticals Inc

InteRNA Technologies BV

Iovance Biotherapeutics Inc

Johnson & Johnson

Kite Pharma Inc

Laboratoires Pierre Fabre SA

LipoMedix Pharmaceutical Inc

Loxo Oncology Inc

Lycera Corp

MacroGenics Inc

Marina Biotech Inc

MaxiVAX SA

Medicenna Therapeutics Corp

MedImmune LLC

Merck & Co Inc

Merck KGaA

Mirati Therapeutics Inc

Moleculin Biotech Inc

MTG Biotherapeutics Inc

NanoCarrier Co Ltd

NantKwest Inc

Nektar Therapeutics

Novartis AG

OncoTherapy Science Inc

Oncovir Inc

Ono Pharmaceutical Co Ltd

Optimum Therapeutics LLC

Oxford BioTherapeutics Ltd

Pfizer Inc

Pharma Mar SA

Philogen SpA

Pieris Pharmaceuticals Inc

Plexxikon Inc

Polaris Pharmaceuticals Inc

Provecs Medical GmbH (Inactive)

Provectus Biopharmaceuticals Inc

PsiOxus Therapeutics Ltd

Rexahn Pharmaceuticals Inc

Samyang Holdings Corp

Sanofi

Sareum Holdings Plc

Shionogi & Co Ltd

Sierra Oncology Inc

Sillajen Biotherapeutics

Sitka Biopharma Inc

Sorrento Therapeutics Inc

Spectrum Pharmaceuticals Inc

Stemline Therapeutics Inc

Sun Pharma Advanced Research Company Ltd

Taiwan Liposome Company Ltd

Taris Biomedical LLC

Theralase Technologies Inc

Tocagen Inc

Tolero Pharmaceuticals Inc

Transgene SA

UroGen Pharma Ltd

Vaccibody AS

Vakzine Projekt Management GmbH

Vault Pharma Inc

Vaxeal Holding SA

Vaxiion Therapeutics Inc

Viralytics Ltd

Vyriad Inc

Zymeworks Inc

Table of Contents

1 Table of Contents

1 Table of Contents 4

1.1 List of Tables 5

1.2 List of Figures 8

2 Introduction 9

2.1 Bladder and Ureter Cancer Report Coverage 9

2.2 Ureter Cancer – Overview 9

2.3 Bladder Cancer – Overview 9

3 Therapeutics Development 10

3.1 Ureter Cancer 10

3.2 Bladder Cancer 14

4 Therapeutics Assessment 34

4.1 Ureter Cancer 34

4.2 Bladder Cancer 41

5 Companies Involved in Therapeutics Development 58

5.1 Ureter Cancer 58

5.2 Bladder Cancer 61

6 Dormant Projects 125

6.1 Bladder Cancer 125

7 Discontinued Products 131

7.1 Bladder Cancer 131

8 Product Development Milestones 133

8.1 Ureter Cancer 133

8.2 Bladder Cancer 135

9 Appendix 149

9.1 Methodology 149

9.2 Coverage 149

9.3 Secondary Research 149

9.4 Primary Research 149

9.5 Expert Panel Validation 149

9.6 Contact Us 150

9.7 Disclaimer 150

List of Tables

1.1 List of Tables

Table 1: Number of Products under Development for Ureter Cancer 10

Table 2: Number of Products under Development by Companies, Ureter Cancer 11

Table 3: Number of Products under Development by Universities/Institutes, Ureter Cancer 12

Table 4: Products under Development by Companies, Ureter Cancer 13

Table 5: Products under Development by Universities/Institutes, Ureter Cancer 13

Table 6: Number of Products under Development for Bladder Cancer 14

Table 7: Number of Products under Development by Companies, Bladder Cancer 16

Table 8: Number of Products under Development by Universities/Institutes, Bladder Cancer 21

Table 9: Products under Development by Companies, Bladder Cancer 22

Table 10: Products under Development by Universities/Institutes, Bladder Cancer 32

Table 11: Number of Products by Stage and Target, Ureter Cancer 35

Table 12: Number of Products by Stage and Mechanism of Action, Ureter Cancer 37

Table 13: Number of Products by Stage and Route of Administration, Ureter Cancer 39

Table 14: Number of Products by Stage and Molecule Type, Ureter Cancer 40

Table 15: Number of Products by Stage and Target, Bladder Cancer 42

Table 16: Number of Products by Stage and Mechanism of Action, Bladder Cancer 48

Table 17: Number of Products by Stage and Route of Administration, Bladder Cancer 55

Table 18: Number of Products by Stage and Molecule Type, Bladder Cancer 57

Table 19: Ureter Cancer – Pipeline by Altor BioScience Corp 58

Table 20: Ureter Cancer – Pipeline by Eisai Co Ltd 58

Table 21: Ureter Cancer – Pipeline by Exelixis Inc 59

Table 22: Ureter Cancer – Pipeline by GlaxoSmithKline Plc 59

Table 23: Ureter Cancer – Pipeline by MedImmune LLC 60

Table 24: Ureter Cancer – Pipeline by Merck & Co Inc 60

Table 25: Bladder Cancer – Pipeline by 4SC AG 61

Table 26: Bladder Cancer – Pipeline by Abivax SA 61

Table 27: Bladder Cancer – Pipeline by Adaptimmune Therapeutics Plc 62

Table 28: Bladder Cancer – Pipeline by ADC Therapeutics Sarl 62

Table 29: Bladder Cancer – Pipeline by Altor BioScience Corp 63

Table 30: Bladder Cancer – Pipeline by AndroScience Corp 63

Table 31: Bladder Cancer – Pipeline by ANP Technologies Inc 64

Table 32: Bladder Cancer – Pipeline by APIM Therapeutics AS 64

Table 33: Bladder Cancer – Pipeline by Archivel Farma SL 65

Table 34: Bladder Cancer – Pipeline by Argos Therapeutics Inc 65

Table 35: Bladder Cancer – Pipeline by Arno Therapeutics Inc 66

Table 36: Bladder Cancer – Pipeline by Array BioPharma Inc 66

Table 37: Bladder Cancer – Pipeline by Asana BioSciences LLC 67

Table 38: Bladder Cancer – Pipeline by Asieris Pharmaceuticals Co Ltd 67

Table 39: Bladder Cancer – Pipeline by Astellas Pharma Inc 68

Table 40: Bladder Cancer – Pipeline by Astex Pharmaceuticals Inc 68

Table 41: Bladder Cancer – Pipeline by AstraZeneca Plc 69

Table 42: Bladder Cancer – Pipeline by AVEO Pharmaceuticals Inc 69

Table 43: Bladder Cancer – Pipeline by Bavarian Nordic A/S 70

Table 44: Bladder Cancer – Pipeline by Bayer AG 70

Table 45: Bladder Cancer – Pipeline by Biocad 71

Table 46: Bladder Cancer – Pipeline by BioCancell Ltd 71

Table 47: Bladder Cancer – Pipeline by Biohaven Pharmaceutical Holding Company Ltd 72

Table 48: Bladder Cancer – Pipeline by Biomics Biotechnologies Co Ltd 72

Table 49: Bladder Cancer – Pipeline by Biotest AG 73

Table 50: Bladder Cancer – Pipeline by Boehringer Ingelheim GmbH 73

Table 51: Bladder Cancer – Pipeline by Bristol-Myers Squibb Co 74

Table 52: Bladder Cancer – Pipeline by Celgene Corp 74

Table 53: Bladder Cancer – Pipeline by Celldex Therapeutics Inc 75

Table 54: Bladder Cancer – Pipeline by Celprogen Inc 75

Table 55: Bladder Cancer – Pipeline by Celsion Corp 76

Table 56: Bladder Cancer – Pipeline by Celyad SA 76

Table 57: Bladder Cancer – Pipeline by Cleveland BioLabs Inc 77

Table 58: Bladder Cancer – Pipeline by Cold Genesys Inc 77

Table 59: Bladder Cancer – Pipeline by Corvus Pharmaceuticals Inc 78

Table 60: Bladder Cancer – Pipeline by CytomX Therapeutics Inc 78

Table 61: Bladder Cancer – Pipeline by Cytori Therapeutics Inc 79

Table 62: Bladder Cancer – Pipeline by Daiichi Sankyo Co Ltd 79

Table 63: Bladder Cancer – Pipeline by Eisai Co Ltd 80

Table 64: Bladder Cancer – Pipeline by Eleven Biotherapeutics Inc 80

Table 65: Bladder Cancer – Pipeline by Eli Lilly and Co 81

Table 66: Bladder Cancer – Pipeline by Elsalys Biotech SAS 82

Table 67: Bladder Cancer – Pipeline by EpiThany Inc 82

Table 68: Bladder Cancer – Pipeline by Esperance Pharmaceuticals Inc 83

Table 69: Bladder Cancer – Pipeline by Exelixis Inc 83

Table 70: Bladder Cancer – Pipeline by Exicure Inc 84

Table 71: Bladder Cancer – Pipeline by F. Hoffmann-La Roche Ltd 84

Table 72: Bladder Cancer – Pipeline by Five Prime Therapeutics Inc 85

Table 73: Bladder Cancer – Pipeline by Gene Signal International SA 85

Table 74: Bladder Cancer – Pipeline by Genentech Inc 86

List of Figures

1.2 List of Figures

Figure 1: Number of Products under Development for Ureter Cancer 10

Figure 2: Number of Products under Development by Companies, Ureter Cancer 11

Figure 3: Number of Products under Development by Universities/Institutes, Ureter Cancer 12

Figure 4: Number of Products under Development for Bladder Cancer 14

Figure 5: Number of Products under Development by Companies, Bladder Cancer 15

Figure 6: Number of Products under Development by Universities/Institutes, Bladder Cancer 20

Figure 7: Number of Products by Top 10 Targets, Ureter Cancer 34

Figure 8: Number of Products by Stage and Top 10 Targets, Ureter Cancer 34

Figure 9: Number of Products by Top 10 Mechanism of Actions, Ureter Cancer 36

Figure 10: Number of Products by Stage and Top 10 Mechanism of Actions, Ureter Cancer 36

Figure 11: Number of Products by Routes of Administration, Ureter Cancer 38

Figure 12: Number of Products by Stage and Top 10 Routes of Administration, Ureter Cancer 38

Figure 13: Number of Products by Molecule Types, Ureter Cancer 39

Figure 14: Number of Products by Stage and Molecule Types, Ureter Cancer 40

Figure 15: Number of Products by Top 10 Targets, Bladder Cancer 41

Figure 16: Number of Products by Stage and Top 10 Targets, Bladder Cancer 41

Figure 17: Number of Products by Top 10 Mechanism of Actions, Bladder Cancer 47

Figure 18: Number of Products by Stage and Top 10 Mechanism of Actions, Bladder Cancer 47

Figure 19: Number of Products by Routes of Administration, Bladder Cancer 54

Figure 20: Number of Products by Stage and Routes of Administration, Bladder Cancer 54

Figure 21: Number of Products by Top 10 Molecule Types, Bladder Cancer 56

Figure 22: Number of Products by Stage and Top 10 Molecule Types, Bladder Cancer 56

    Pricing

Discounts available for multiple purchases.

reportstore@marketline.com
+44 20 7947 2960

Saved reports