Table of Contents
1 Table of Contents
1.1 List of Figures
2 Innovation in Prefilled Syringes Market – Executive Summary
2.1 Move towards Home Healthcare Drives the Use of Prefilled Syringes and Autoinjection Devices
2.2 Legislation Regarding Needlestick Injuries Increases Popularity of Prefilled Syringes with Integrated Safety Mechanisms
2.3 The Rise of Biologic Therapies Requires a Concurrent Rise in Prefilled Syringe Technologies
3 Innovation in Prefilled Syringes – Introduction
3.1 What are Prefilled Syringes?
3.2 The Current Position of Prefilled Syringes in the Pharmaceutical Market
3.3 Factors Fueling Growth of Prefilled Syringes
3.4 Issues around the Use of Prefilled Syringes
3.5 Where Does Innovation Lie?
4 Innovation in Prefilled Syringes – Current Device Technologies and Associated Drivers and Barriers
4.1 Glass Syringes versus Plastic Syringes
4.1.1 Fragility
4.1.2 Dimensional Variability
4.1.3 Siliconization
4.1.4 Delamination
4.1.5 Tungsten Contamination
4.2 Autoinjection Devices
4.3 Safety Devices on Prefilled Syringes
4.4 Prefilled Diluent Syringes
4.5 Biologics Driving Innovation in Prefilled Syringes
5 Innovation in Prefilled Syringes – Formulation Considerations and Challenges for Pharmaceutical Companies
5.1 Drug Viscosity
5.2 Extractables and Leachables
5.3 Lyophilized Drugs versus Liquid-stable Formulations
6 Innovations in Prefilled Syringes – Overcoming Current Barriers and Trends in Development
6.1 Innovative Ways of Gaining Life Cycle Extensions for Existing Products
6.2 Plastic Syringes Offer Some Improvements over Traditional Glass Syringes
6.2.1 Polypropylene
6.2.1.1 Aguettant’s Prefilled Syringe
6.2.2 Cyclo-olefin Polymers and Co-polymers
6.2.2.1 West Pharmaceuticals Daikyo Crystal Zenith Prefilled Syringe
6.3 Extractables and Leachables
6.3.1 Glass Coatings – Reducing Silicone and Silicone Baking
6.3.2 Coated Stoppers
6.4 Safety Innovations
6.5 Integrated Needles – Advancements on the Luer Lock System
6.6 Filling Technologies and Removing the Air Bubble
6.7 Needle Length – Reducing Length can Increase Accuracy of Subcutaneous Injections
6.8 Manufacturing Advances – Sterilizing Syringes
6.8.1 Restricted Access Barrier Systems
6.8.2 Electron Beam Sterilization Tunnels
6.9 Automating and Streamlining the Manufacture of Prefilled Syringes
6.10 Manufacturing Flexibility and Integrated Systems
6.11 Testing of Prefilled Syringes
6.12 Customization of Prefilled Syringes
6.13 Self-injection Improvements
6.14 Patient-centric Focus for CMOs
7 Appendix
7.1 Market Definitions
7.2 Abbreviations
7.3 Bibliography
Research Methodology
7.3.1 Coverage
7.3.2 Secondary Research
7.3.3 Primary Research
7.3.4 Expert Panel Validation
7.4 Contact Us
7.5 Disclaimer